Literature DB >> 21321792

Application of silicon photomultipliers to positron emission tomography.

Emilie Roncali1, Simon R Cherry.   

Abstract

Historically, positron emission tomography (PET) systems have been based on scintillation crystals coupled to photomultipliers tubes (PMTs). However, the limited quantum efficiency, bulkiness, and relatively high cost per unit surface area of PMTs, along with the growth of new applications for PET, offers opportunities for other photodetectors. Among these, small-animal scanners, hybrid PET/MRI systems, and incorporation of time-of-flight information are of particular interest and require low-cost, compact, fast, and magnetic field compatible photodetectors. With high quantum efficiency and compact structure, avalanche photodiodes (APDs) overcome several of the drawbacks of PMTs, but this is offset by degraded signal-to-noise and timing properties. Silicon photomultipliers (SiPMs) offer an alternative solution, combining many of the advantages of PMTs and APDs. They have high gain, excellent timing properties and are insensitive to magnetic fields. At the present time, SiPM technology is rapidly developing and therefore an investigation into optimal design and operating conditions is underway together with detailed characterization of SiPM-based PET detectors. Published data are extremely promising and show good energy and timing resolution, as well as the ability to decode small scintillator arrays. SiPMs clearly have the potential to be the photodetector of choice for some, or even perhaps most, PET systems.

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Year:  2011        PMID: 21321792      PMCID: PMC3069330          DOI: 10.1007/s10439-011-0266-9

Source DB:  PubMed          Journal:  Ann Biomed Eng        ISSN: 0090-6964            Impact factor:   3.934


  22 in total

1.  Characterization of silicon avalanche photodiodes for photon correlation measurements. 2: Active quenching.

Authors:  R G Brown; R Jones; J G Rarity; K D Ridley
Journal:  Appl Opt       Date:  1987-06-15       Impact factor: 1.980

2.  Performance evaluation of the microPET focus: a third-generation microPET scanner dedicated to animal imaging.

Authors:  Yuan-Chuan Tai; Ananya Ruangma; Douglas Rowland; Stefan Siegel; Danny F Newport; Patrick L Chow; Richard Laforest
Journal:  J Nucl Med       Date:  2005-03       Impact factor: 10.057

3.  Characterization of silicon avalanche photodiodes for photon correlation measurements. 1: Passive quenching.

Authors:  R G Brown; K D Ridley; J G Rarity
Journal:  Appl Opt       Date:  1986-11-15       Impact factor: 1.980

4.  A novel, SiPM-array-based, monolithic scintillator detector for PET.

Authors:  Dennis R Schaart; Herman T van Dam; Stefan Seifert; Ruud Vinke; Peter Dendooven; Herbert Löhner; Freek J Beekman
Journal:  Phys Med Biol       Date:  2009-05-15       Impact factor: 3.609

5.  Monolithic scintillator PET detectors with intrinsic depth-of-interaction correction.

Authors:  Marnix C Maas; Dennis R Schaart; D J Jan van der Laan; Peter Bruyndonckx; Cedric Lemaître; Freek J Beekman; Carel W E van Eijk
Journal:  Phys Med Biol       Date:  2009-03-05       Impact factor: 3.609

6.  Simultaneous PET and MR imaging.

Authors:  Y Shao; S R Cherry; K Farahani; K Meadors; S Siegel; R W Silverman; P K Marsden
Journal:  Phys Med Biol       Date:  1997-10       Impact factor: 3.609

7.  A combined PET/CT scanner for clinical oncology.

Authors:  T Beyer; D W Townsend; T Brun; P E Kinahan; M Charron; R Roddy; J Jerin; J Young; L Byars; R Nutt
Journal:  J Nucl Med       Date:  2000-08       Impact factor: 10.057

Review 8.  Clinical myocardial perfusion PET/CT.

Authors:  Marcelo F Di Carli; Sharmila Dorbala; Jolene Meserve; Georges El Fakhri; Arkadiusz Sitek; Stephen C Moore
Journal:  J Nucl Med       Date:  2007-05       Impact factor: 10.057

9.  Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias.

Authors:  Lisa Mosconi; Wai H Tsui; Karl Herholz; Alberto Pupi; Alexander Drzezga; Giovanni Lucignani; Eric M Reiman; Vjera Holthoff; Elke Kalbe; Sandro Sorbi; Janine Diehl-Schmid; Robert Perneczky; Francesca Clerici; Richard Caselli; Bettina Beuthien-Baumann; Alexander Kurz; Satoshi Minoshima; Mony J de Leon
Journal:  J Nucl Med       Date:  2008-02-20       Impact factor: 10.057

10.  A prototype PET scanner with DOI-encoding detectors.

Authors:  Yongfeng Yang; Yibao Wu; Jinyi Qi; Sara St James; Huini Du; Purushottam A Dokhale; Kanai S Shah; Richard Farrell; Simon R Cherry
Journal:  J Nucl Med       Date:  2008-06-13       Impact factor: 10.057

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  42 in total

1.  Innovative Physics and Engineering Research in Nuclear Medicine and Molecular Imaging: A Message from the Associate Editor.

Authors:  Jae Sung Lee
Journal:  Nucl Med Mol Imaging       Date:  2015-10-26

2.  A Prototype Detector for a Novel High-Resolution PET System: BazookaPET.

Authors:  Ryeojin Park; Brian W Miller; Abhinav K Jha; Lars R Furenlid; William C J Hunter; Harrison H Barrett
Journal:  IEEE Nucl Sci Symp Conf Rec (1997)       Date:  2012 Oct-Nov

Review 3.  Innovations in Instrumentation for Positron Emission Tomography.

Authors:  Eric Berg; Simon R Cherry
Journal:  Semin Nucl Med       Date:  2018-03-12       Impact factor: 4.446

4.  Evaluation of Matrix9 silicon photomultiplier array for small-animal PET.

Authors:  Junwei Du; Jeffrey P Schmall; Yongfeng Yang; Kun Di; Emilie Roncali; Gregory S Mitchell; Steve Buckley; Carl Jackson; Simon R Cherry
Journal:  Med Phys       Date:  2015-02       Impact factor: 4.071

5.  Reaching 200-ps timing resolution in a time-of-flight and depth-of-interaction positron emission tomography detector using phosphor-coated crystals and high-density silicon photomultipliers.

Authors:  Sun Il Kwon; Alessandro Ferri; Alberto Gola; Eric Berg; Claudio Piemonte; Simon R Cherry; Emilie Roncali
Journal:  J Med Imaging (Bellingham)       Date:  2016-11-23

6.  Thermal regulation of tightly packed solid-state photodetectors in a 1 mm(3) resolution clinical PET system.

Authors:  D L Freese; A Vandenbroucke; D Innes; F W Y Lau; D F C Hsu; P D Reynolds; Craig S Levin
Journal:  Med Phys       Date:  2015-01       Impact factor: 4.071

Review 7.  Advances in PET/MR instrumentation and image reconstruction.

Authors:  Jorge Cabello; Sibylle I Ziegler
Journal:  Br J Radiol       Date:  2016-07-22       Impact factor: 3.039

Review 8.  Instrumentation for Time-of-Flight Positron Emission Tomography.

Authors:  Muhammad Nasir Ullah; Eva Pratiwi; Jimin Cheon; Hojong Choi; Jung Yeol Yeom
Journal:  Nucl Med Mol Imaging       Date:  2016-02-22

Review 9.  Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease.

Authors:  Feliks Kogan; Audrey P Fan; Garry E Gold
Journal:  Quant Imaging Med Surg       Date:  2016-12

10.  Impact of a multiple mice holder on quantitation of high-throughput MicroPET imaging with and without Ct attenuation correction.

Authors:  Frezghi Habte; Gang Ren; Timothy C Doyle; Hongguang Liu; Zhen Cheng; David S Paik
Journal:  Mol Imaging Biol       Date:  2013-10       Impact factor: 3.488

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