Literature DB >> 26316682

A Prototype Detector for a Novel High-Resolution PET System: BazookaPET.

Ryeojin Park1, Brian W Miller2, Abhinav K Jha1, Lars R Furenlid1, William C J Hunter3, Harrison H Barrett1.   

Abstract

We have designed and are developing a novel proof-of-concept PET system called BazookaPET. In order to complete the PET configuration, at least two detector elements are required to detect positron-electron annihilation events. Each detector element of the BazookaPET has two independent data acquisition channels. One side of the scintillation crystal is optically coupled to a 4×4 silicon photomultiplier (SiPM) array and the other side is a CCD-based gamma camera. Using these two separate channels, we can obtain data with high energy, temporal and spatial resolution data by associating the data outputs via several maximum-likelihood estimation (MLE) steps. In this work, we present the concept of the system and the prototype detector element. We focus on characterizing individual detector channels, and initial experimental calibration results are shown along with preliminary performance-evaluation results. We measured energy resolution and the integrated traces of the slit-beam images from both detector channel outputs. A photo-peak energy resolution of ~5.3% FWHM was obtained from the SiPM and ~48% FWHM from the CCD at 662 keV. We assumed SiPM signals follow Gaussian statistics and estimated the 2D interaction position using MLE. Based on our the calibration experiments, we computed the Cramér-Rao bound (CRB) for the SiPM detector channel and found that the CRB resolution is better than 1 mm in the center of the crystal.

Entities:  

Keywords:  CCD-based gamma camera; PET imaging; image intensifier; molecular imaging; monolithic LaBr3:Ce; silicon photomultiplier (SiPM)

Year:  2012        PMID: 26316682      PMCID: PMC4548890          DOI: 10.1109/NSSMIC.2012.6551486

Source DB:  PubMed          Journal:  IEEE Nucl Sci Symp Conf Rec (1997)        ISSN: 1095-7863


  18 in total

Review 1.  Use of positron emission tomography in animal research.

Authors:  S R Cherry; S S Gambhir
Journal:  ILAR J       Date:  2001

2.  An enhanced high-resolution EMCCD-based gamma camera using SiPM side detection.

Authors:  J W T Heemskerk; M A N Korevaar; J Huizenga; R Kreuger; D R Schaart; M C Goorden; F J Beekman
Journal:  Phys Med Biol       Date:  2010-10-28       Impact factor: 3.609

3.  Recent advances in BazookaSPECT: Real-time data processing and the development of a gamma-ray microscope.

Authors:  Brian W Miller; Harrison H Barrett; Lars R Furenlid; H Bradford Barber; Robert J Hunter
Journal:  Nucl Instrum Methods Phys Res A       Date:  2008-06-11       Impact factor: 1.455

4.  Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals.

Authors:  S P Hume; R N Gunn; T Jones
Journal:  Eur J Nucl Med       Date:  1998-02

5.  Improved EMCCD gamma camera performance by SiPM pre-localization.

Authors:  S Salvador; M A N Korevaar; J W T Heemskerk; R Kreuger; J Huizenga; S Seifert; D R Schaart; F J Beekman
Journal:  Phys Med Biol       Date:  2012-11-02       Impact factor: 3.609

6.  A full-field modular gamma camera.

Authors:  T D Milster; J N Aarsvold; H H Barrett; A L Landesman; L S Mar; D D Patton; T J Roney; R K Rowe; R H Seacat
Journal:  J Nucl Med       Date:  1990-05       Impact factor: 10.057

7.  Simulation study of spatial resolution and sensitivity for the tapered depth of interaction PET detectors for small animal imaging.

Authors:  Sara St James; Yongfeng Yang; Spencer L Bowen; Jinyi Qi; Simon R Cherry
Journal:  Phys Med Biol       Date:  2009-12-21       Impact factor: 3.609

8.  Calibration Method for ML Estimation of 3D Interaction Position in a Thick Gamma-Ray Detector.

Authors:  William C J Hunter; Harrison H Barrett; Lars R Furenlid
Journal:  IEEE Trans Nucl Sci       Date:  2009-02-10       Impact factor: 1.679

Review 9.  Recent development in PET instrumentation.

Authors:  By Hao Peng; Craig S Levin
Journal:  Curr Pharm Biotechnol       Date:  2010-09-01       Impact factor: 2.837

10.  Progress in BazookaSPECT: High-Resolution, Dynamic Scintigraphy with Large-Area Imagers.

Authors:  Brian W Miller; H Bradford Barber; Harrison H Barrett; Zhonglin Liu; Vivek V Nagarkar; Lars R Furenlid
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2012-08-12
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  1 in total

1.  The iQID camera: An ionizing-radiation quantum imaging detector.

Authors:  Brian W Miller; Stephanie J Gregory; Erin S Fuller; Harrison H Barrett; H Bradford Barber; Lars R Furenlid
Journal:  Nucl Instrum Methods Phys Res A       Date:  2014-12-11       Impact factor: 1.455

  1 in total

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