OBJECTIVE: To determine, in serial fixed-flexion (FF) radiographs of subjects with knee osteoarthritis (KOA), the importance of, and basis for, the effect of alignment of the medial tibial plateau (MTP), as determined by the inter-margin distance (IMD), on joint space narrowing (JSN). METHODS: Baseline and 12-month X-rays of 590 knees with Kellgren and Lawrence grade (KLG) 2/3 OA from the public-release dataset of the Osteoarthritis Initiative (OAI) were assigned to subgroups based upon IMD at baseline (IMD(BL)) and the difference between IMD(BL) and IMD(12 mos). Relationships of JSN to IMD(BL) and to the difference between IMD(BL and) IMD(12 mos) were evaluated. RESULTS: In all 590 knees, mean JSN was 0.13 ± 0.51 mm (P<0.0001) and MTP alignment and replication of IMD(BL) in the 12-month film were, in general, poor. JSN was significantly (P=0.012) more rapid in Subgroup A (IMD≤1.70 mm at both time points) than in Subgroup B (both IMDs>1.70 mm): 0.15 ± 0.43; 0.08 ± 0.47. Within Subgroup B we identified a subset, Subgroup B1, in which, although alignment was poor at both time points, the large IMD(BL) was, by chance, highly reproduced by IMD(12 mos) (difference between the two IMDs=0.01 ± 0.27 mm, NS). JSN in Subgroup B1 was 0.06 ± 0.41 mm and did not differ from that in other knees of Subgroup B (P=0.87). The standardized response mean (SRM) in all 590 knees and Subgroups A, B and B1 was 0.25, 0.34, 0.17 and 0.06, respectively. Independent of IMD(BL), JSN correlated significantly with the difference between the IMDs in the two radiographs (r=0.17, P=0.0001). CONCLUSION: Skewed MTP alignment in serial films and poor replication of IMD(BL) in the follow-up exam affect JSN measurement. The magnitude of change in joint space width (JSW) related to the poor quality of alignment that is common with the FF view jeopardizes accurate evaluation of JSN. Published by Elsevier Ltd.
OBJECTIVE: To determine, in serial fixed-flexion (FF) radiographs of subjects with knee osteoarthritis (KOA), the importance of, and basis for, the effect of alignment of the medial tibial plateau (MTP), as determined by the inter-margin distance (IMD), on joint space narrowing (JSN). METHODS: Baseline and 12-month X-rays of 590 knees with Kellgren and Lawrence grade (KLG) 2/3 OA from the public-release dataset of the Osteoarthritis Initiative (OAI) were assigned to subgroups based upon IMD at baseline (IMD(BL)) and the difference between IMD(BL) and IMD(12 mos). Relationships of JSN to IMD(BL) and to the difference between IMD(BL and) IMD(12 mos) were evaluated. RESULTS: In all 590 knees, mean JSN was 0.13 ± 0.51 mm (P<0.0001) and MTP alignment and replication of IMD(BL) in the 12-month film were, in general, poor. JSN was significantly (P=0.012) more rapid in Subgroup A (IMD≤1.70 mm at both time points) than in Subgroup B (both IMDs>1.70 mm): 0.15 ± 0.43; 0.08 ± 0.47. Within Subgroup B we identified a subset, Subgroup B1, in which, although alignment was poor at both time points, the large IMD(BL) was, by chance, highly reproduced by IMD(12 mos) (difference between the two IMDs=0.01 ± 0.27 mm, NS). JSN in Subgroup B1 was 0.06 ± 0.41 mm and did not differ from that in other knees of Subgroup B (P=0.87). The standardized response mean (SRM) in all 590 knees and Subgroups A, B and B1 was 0.25, 0.34, 0.17 and 0.06, respectively. Independent of IMD(BL), JSN correlated significantly with the difference between the IMDs in the two radiographs (r=0.17, P=0.0001). CONCLUSION: Skewed MTP alignment in serial films and poor replication of IMD(BL) in the follow-up exam affect JSN measurement. The magnitude of change in joint space width (JSW) related to the poor quality of alignment that is common with the FF view jeopardizes accurate evaluation of JSN. Published by Elsevier Ltd.
Authors: Kenneth D Brandt; Steven A Mazzuca; Thierry Conrozier; Jane E Dacre; Charles G Peterfy; Diego Provvedini; Phillipe Ravaud; Alain Taccoen; Eric Vignon Journal: J Rheumatol Date: 2002-06 Impact factor: 4.666
Authors: M-P H Le Graverand; S Mazzuca; M Lassere; A Guermazi; E Pickering; K Brandt; C Peterfy; G Cline; M Nevitt; T Woodworth; P Conaghan; E Vignon Journal: Osteoarthritis Cartilage Date: 2006 Impact factor: 6.576
Authors: S Botha-Scheepers; M Kloppenburg; H M Kroon; M-P Hellio Le Graverand; F C Breedveld; P Ravaud; M Dougados Journal: Osteoarthritis Cartilage Date: 2006-10-30 Impact factor: 6.576
Authors: M-P Hellio Le Graverand; E P Vignon; K D Brandt; S A Mazzuca; M Piperno; R Buck; H C Charles; D J Hunter; C G Jackson; V Byers Kraus; T M Link; T J Schnitzer; A Vaz; B Wyman Journal: Ann Rheum Dis Date: 2008-02-07 Impact factor: 19.103
Authors: S A Mazzuca; M-P Hellio Le Graverand; E Vignon; D J Hunter; C G Jackson; V B Kraus; T M Link; T J Schnitzer; A Vaz; H C Charles Journal: Osteoarthritis Cartilage Date: 2008-06-02 Impact factor: 6.576
Authors: Kenneth D Brandt; Steven A Mazzuca; Barry P Katz; Kathleen A Lane; Kenneth A Buckwalter; David E Yocum; Frederick Wolfe; Thomas J Schnitzer; Larry W Moreland; Susan Manzi; John D Bradley; Leena Sharma; Chester V Oddis; Steven T Hugenberg; Louis W Heck Journal: Arthritis Rheum Date: 2005-07
Authors: F Eckstein; A Guermazi; G Gold; J Duryea; M-P Hellio Le Graverand; W Wirth; C G Miller Journal: Osteoarthritis Cartilage Date: 2014-10 Impact factor: 6.576
Authors: Camille M Parsons; Andrew Judge; Kirsten Leyland; Olivier Bruyère; Florence Petit Dop; Roland Chapurlat; Jean-Yves Reginster; Mark H Edwards; Elaine M Dennison; Cyrus Cooper; Hazel Inskip Journal: Arthritis Care Res (Hoboken) Date: 2019-02 Impact factor: 4.794
Authors: Mukundan Attur; Svetlana Krasnokutsky; Hua Zhou; Jonathan Samuels; Gregory Chang; Jenny Bencardino; Pamela Rosenthal; Leon Rybak; Janet L Huebner; Virginia B Kraus; Steven B Abramson Journal: Arthritis Res Ther Date: 2020-09-10 Impact factor: 5.156