Camille M Parsons1, Andrew Judge2, Kirsten Leyland3, Olivier Bruyère4, Florence Petit Dop5, Roland Chapurlat6, Jean-Yves Reginster4, Mark H Edwards7, Elaine M Dennison1, Cyrus Cooper8, Hazel Inskip9. 1. University of Southampton, Southampton, UK. 2. University of Southampton, Southampton, and University of Oxford, Oxford, UK. 3. University of Oxford, Oxford, and University of Bristol, Bristol, UK. 4. University of Liège, Liège, Belgium. 5. Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France. 6. INSERM UMR 1033, Hôpital Edouard Herriot, Université de Lyon, Lyon, France. 7. University of Southampton and Southampton General Hospital, Southampton, and Portsmouth Hospitals NHS Trust, Portsmouth, UK. 8. University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, and University of Oxford, Oxford, UK. 9. University of Southampton, and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Abstract
OBJECTIVE: Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. METHODS: Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. RESULTS: Between consecutive years, 57-69% of participants had an apparent decrease (change <0) in JSW, while 31-43% of participants had annual changes indicating improvement in JSW. The RCI identified JSW decreases in only 6.0% of patients between baseline and year 1, and in 4.5% of patients between the remaining study years. The apparent increases in JSW were almost eliminated between baseline and year 1, and between years 1 and 2 only 1.3% of patients had a significant increase, dropping to 0.9% between years 2 and 3. CONCLUSION: The RCI provides a method to identify change in JSW, removing many apparent changes that are likely to be due to measurement error. This method appears to be useful for assessing change in JSW from radiographs in clinical and research settings.
RCT Entities:
OBJECTIVE:Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index (RCI) determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RCI as a novel approach to estimating osteoarthritis progression. METHODS: Data were from 167 men and 392 women with knee osteoarthritis (diagnosed using the American College of Rheumatology criteria) randomized to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis trial (SEKOIA) and assessed annually. The RCI was used to determine whether the magnitude of change in joint space width (JSW) on radiographs between study years was likely to be true or due to measurement error. RESULTS: Between consecutive years, 57-69% of participants had an apparent decrease (change <0) in JSW, while 31-43% of participants had annual changes indicating improvement in JSW. The RCI identified JSW decreases in only 6.0% of patients between baseline and year 1, and in 4.5% of patients between the remaining study years. The apparent increases in JSW were almost eliminated between baseline and year 1, and between years 1 and 2 only 1.3% of patients had a significant increase, dropping to 0.9% between years 2 and 3. CONCLUSION: The RCI provides a method to identify change in JSW, removing many apparent changes that are likely to be due to measurement error. This method appears to be useful for assessing change in JSW from radiographs in clinical and research settings.
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Authors: Reva C Lawrence; David T Felson; Charles G Helmick; Lesley M Arnold; Hyon Choi; Richard A Deyo; Sherine Gabriel; Rosemarie Hirsch; Marc C Hochberg; Gene G Hunder; Joanne M Jordan; Jeffrey N Katz; Hilal Maradit Kremers; Frederick Wolfe Journal: Arthritis Rheum Date: 2008-01
Authors: Mukundan Attur; Svetlana Krasnokutsky; Hua Zhou; Jonathan Samuels; Gregory Chang; Jenny Bencardino; Pamela Rosenthal; Leon Rybak; Janet L Huebner; Virginia B Kraus; Steven B Abramson Journal: Arthritis Res Ther Date: 2020-09-10 Impact factor: 5.156