Literature DB >> 19928069

Design and characterization of a spatially distributed multibeam field emission x-ray source for stationary digital breast tomosynthesis.

Xin Qian1, Ramya Rajaram, Xiomara Calderon-Colon, Guang Yang, Tuyen Phan, David S Lalush, Jianping Lu, Otto Zhou.   

Abstract

Digital breast tomosynthesis (DBT) is a limited angle computed tomography technique that can distinguish tumors from its overlying breast tissues and has potentials for detection of cancers at a smaller size and earlier stage. Current prototype DBT scanners are based on the regular full-field digital mammography systems and require partial isocentric motion of an x-ray tube over certain angular range to record the projection views. This prolongs the scanning time and, in turn, degrades the imaging quality due to motion blur. To mitigate the above limitations, the concept of a stationary DBT (s-DBT) scanner has been recently proposed based on the newly developed spatially distributed multibeam field emission x-ray (MBFEX) source technique using the carbon nanotube. The purpose of this article is to evaluate the performance of the 25-beam MBFEX source array that has been designed and fabricated for the s-DBT system. The s-DBT system records all the projection images by electronically activating the multiple x-ray beams from different viewing angles without any mechanical motion. The configuration of the MBFEX source is close to the published values from the Siemens Mammomat system. The key issues including the x-ray flux, focal spot size, spatial resolution, scanning time, beam-to-beam consistency, and reliability are evaluated using the standard procedures. In this article, the authors describe the design and performance of a distributed x-ray source array specifically designed for the s-DBT system. They evaluate the emission current, current variation, lifetime, and focal spot sizes of the source array. An emission current of up to 18 mA was obtained at 0.5 x 0.3 mm effective focal spot size. The experimentally measured focal spot sizes are comparable to that of a typical commercial mammography tube without motion blurring. Trade-off between the system spatial resolution, x-ray flux, and scanning time are also discussed. Projection images of a breast phantom were collected using the x-ray source array from 25 different viewing angles without motion. These preliminary results demonstrate the feasibility of the proposed s-DBT scanner. The technology has the potential to increase the resolution and reduce the imaging time for DBT. With the present design of 25 views, they demonstrated experimentally the feasibility of achieving 11 s scanning time at full detector resolution with 0.5 x 0.3 mm source resolution without motion blur. The flexibility in configuration of the x-ray source array will also allow system designers to consider imaging geometries that are difficult to achieve with the conventional single-source rotating approach.

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Year:  2009        PMID: 19928069      PMCID: PMC2771710          DOI: 10.1118/1.3213520

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  22 in total

Review 1.  Digital x-ray tomosynthesis: current state of the art and clinical potential.

Authors:  James T Dobbins; Devon J Godfrey
Journal:  Phys Med Biol       Date:  2003-10-07       Impact factor: 3.609

2.  Image quality in two phosphor-based flat panel digital radiographic detectors.

Authors:  Ehsan Samei
Journal:  Med Phys       Date:  2003-07       Impact factor: 4.071

3.  A prototype table-top inverse-geometry volumetric CT system.

Authors:  Taly Gilat Schmidt; Josh Star-Lack; N Robert Bennett; Samuel R Mazin; Edward G Solomon; Rebecca Fahrig; Norbert J Pelc
Journal:  Med Phys       Date:  2006-06       Impact factor: 4.071

4.  Scanning-beam digital x-ray (SBDX) technology for interventional and diagnostic cardiac angiography.

Authors:  Michael A Speidel; Brian P Wilfley; Josh M Star-Lack; Joseph A Heanue; Michael S Van Lysel
Journal:  Med Phys       Date:  2006-08       Impact factor: 4.071

5.  Experimental spectral measurements of heavy K-edge filtered beams for x-ray computed mammotomography.

Authors:  D J Crotty; R L McKinley; M P Tornai
Journal:  Phys Med Biol       Date:  2007-01-10       Impact factor: 3.609

6.  A simple method for determining the modulation transfer function in digital radiography.

Authors:  H Fujita; D Y Tsai; T Itoh; K Doi; J Morishita; K Ueda; A Ohtsuka
Journal:  IEEE Trans Med Imaging       Date:  1992       Impact factor: 10.048

7.  Experimental validation of a three-dimensional linear system model for breast tomosynthesis.

Authors:  Bo Zhao; Jun Zhou; Yue-Houng Hu; Thomas Mertelmeier; Jasmina Ludwig; Wei Zhao
Journal:  Med Phys       Date:  2009-01       Impact factor: 4.071

8.  A dynamic micro-CT scanner based on a carbon nanotube field emission x-ray source.

Authors:  G Cao; Y Z Lee; R Peng; Z Liu; R Rajaram; X Calderon-Colon; L An; P Wang; T Phan; S Sultana; D S Lalush; J P Lu; O Zhou
Journal:  Phys Med Biol       Date:  2009-03-25       Impact factor: 3.609

9.  Cardiac imaging with a high-speed Cine-CT Scanner: preliminary results.

Authors:  M J Lipton; C B Higgins; D Farmer; D P Boyd
Journal:  Radiology       Date:  1984-09       Impact factor: 11.105

Review 10.  Technical principles of dual source CT.

Authors:  Martin Petersilka; Herbert Bruder; Bernhard Krauss; Karl Stierstorfer; Thomas G Flohr
Journal:  Eur J Radiol       Date:  2008-10-07       Impact factor: 3.528

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  22 in total

1.  High resolution stationary digital breast tomosynthesis using distributed carbon nanotube x-ray source array.

Authors:  Xin Qian; Andrew Tucker; Emily Gidcumb; Jing Shan; Guang Yang; Xiomara Calderon-Colon; Shabana Sultana; Jianping Lu; Otto Zhou; Derrek Spronk; Frank Sprenger; Yiheng Zhang; Don Kennedy; Tom Farbizio; Zhenxue Jing
Journal:  Med Phys       Date:  2012-04       Impact factor: 4.071

2.  Multibeam field emission x-ray system with half-scan reconstruction algorithm.

Authors:  Yang Lu; Hengyong Yu; Guohua Cao; Jun Zhao; Ge Wang; Otto Zhou
Journal:  Med Phys       Date:  2010-07       Impact factor: 4.071

3.  Statistical iterative reconstruction to improve image quality for digital breast tomosynthesis.

Authors:  Shiyu Xu; Jianping Lu; Otto Zhou; Ying Chen
Journal:  Med Phys       Date:  2015-09       Impact factor: 4.071

4.  Stationary intraoral digital tomosynthesis using a carbon nanotube X-ray source array.

Authors:  J Shan; A W Tucker; L R Gaalaas; G Wu; E Platin; A Mol; J Lu; O Zhou
Journal:  Dentomaxillofac Radiol       Date:  2015-06-19       Impact factor: 2.419

Review 5.  A review of breast tomosynthesis. Part I. The image acquisition process.

Authors:  Ioannis Sechopoulos
Journal:  Med Phys       Date:  2013-01       Impact factor: 4.071

6.  Dependency of image quality on system configuration parameters in a stationary digital breast tomosynthesis system.

Authors:  Andrew W Tucker; Jianping Lu; Otto Zhou
Journal:  Med Phys       Date:  2013-03       Impact factor: 4.071

7.  Multisource inverse-geometry CT. Part II. X-ray source design and prototype.

Authors:  V Bogdan Neculaes; Antonio Caiafa; Yang Cao; Bruno De Man; Peter M Edic; Kristopher Frutschy; Satish Gunturi; Lou Inzinna; Joseph Reynolds; Mark Vermilyea; David Wagner; Xi Zhang; Yun Zou; Norbert J Pelc; Brian Lounsberry
Journal:  Med Phys       Date:  2016-08       Impact factor: 4.071

8.  Multisource inverse-geometry CT. Part I. System concept and development.

Authors:  Bruno De Man; Jorge Uribe; Jongduk Baek; Dan Harrison; Zhye Yin; Randy Longtin; Jaydeep Roy; Bill Waters; Colin Wilson; Jonathan Short; Lou Inzinna; Joseph Reynolds; V Bogdan Neculaes; Kristopher Frutschy; Bob Senzig; Norbert Pelc
Journal:  Med Phys       Date:  2016-08       Impact factor: 4.071

9.  Carbon nanotube electron field emitters for x-ray imaging of human breast cancer.

Authors:  Emily Gidcumb; Bo Gao; Jing Shan; Christy Inscoe; Jianping Lu; Otto Zhou
Journal:  Nanotechnology       Date:  2014-05-28       Impact factor: 3.874

10.  Comparison of a stationary digital breast tomosynthesis system to magnified 2D mammography using breast tissue specimens.

Authors:  Andrew W Tucker; Jabari Calliste; Emily M Gidcumb; Jaclyn Wu; Cherie M Kuzmiak; Noorie Hyun; Donglin Zeng; Jianping Lu; Otto Zhou; Yueh Z Lee
Journal:  Acad Radiol       Date:  2014-08-27       Impact factor: 3.173

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