Literature DB >> 177727

Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells.

J Hay, J H Subak-Sharpe.   

Abstract

Three mutants of herpes simplex virus (HSV) have been isolated which form plaques in the presence of 100 mug/ml phosphonoacetic acid (PPA). All three mutants (3 from HSV-1 strain 17 syn+, 14 from HSV-1 strain 17 syn, and 19 from HSV-2) induce viral DNA synthesis and viral DNA polymerase activity, and these are much less sensitive to PPA than the wild-type virus. The results support the hypothesis that PPA interacts directly with the viral DNA polymerase protein, at least part of which is virus coded.

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Year:  1976        PMID： 177727     DOI： 10.1099/0022-1317-31-1-145

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  45 in total

1.  Herpes simplex virus DNA polymerase, thymidine kinase and deoxyribonuclease activities in cells infected with wild type, ultraviolet-irradiated and defective virus.

Authors:  Y Becker; B Gutter; Y Cohen; N Chejanovsky; S Rabkin; B Fridlender
Journal:  Arch Virol       Date:  1979       Impact factor: 2.574

2.  Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis.

Authors:  C A Wu; N J Nelson; D J McGeoch; M D Challberg
Journal:  J Virol       Date:  1988-02       Impact factor: 5.103

3.  Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus.

Authors:  B Fridlender; N Chejanovsky; Y Becker
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191

4.  Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate.

Authors:  J M Reno; L F Lee; J A Boezi
Journal:  Antimicrob Agents Chemother       Date:  1978-02       Impact factor: 5.191

5.  Isolation and characterization of herpes simplex virus type 1 host range mutants defective in viral DNA synthesis.

Authors:  E P Carmichael; M J Kosovsky; S K Weller
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

6.  Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.

Authors:  D M Coen; H E Fleming; L K Leslie; M J Retondo
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

7.  A method for identifying the viral genes required for herpesvirus DNA replication.

Authors:  M D Challberg
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

8.  Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription.

Authors:  L M Schang; J Phillips; P A Schaffer
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

9.  Resistance of herpes simplex virus to 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine: physical mapping of drug synergism within the viral DNA polymerase locus.

Authors:  C S Crumpacker; P N Kowalsky; S A Oliver; L E Schnipper; A K Field
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

10.  Effect of aphidicolin on vaccinia virus: isolation of an aphidicolin-resistant mutant.

Authors:  F M DeFilippes
Journal:  J Virol       Date:  1984-11       Impact factor: 5.103
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