Literature DB >> 6283139

Isolation and preliminary characterization of a phosphonoacetic acid-resistant and temperature-sensitive mutant of herpes simplex virus type 1.

J I Daksis, M M Priemer, V L Chan.   

Abstract

A group of 43 phosphonoacetic acid (PAA)-resistant mutants of herpes simplex virus type 1 was isolated after the mutagenesis of infected cells with nitrosoguanidine. One of these mutants, designated PAA1rts1, was found to be temperature sensitive (ts), that is, unable to replicate at 39.5 degrees C, the nonpermissive temperature. Recombination analysis of PAA1rts1 indicated that the PAA1r mutation and the ts1 mutation are loosely linked and are located on two separate genes. PAA1rts1 showed a defect in viral DNA synthesis at 39.5 degrees C, which presumably can be attributed to the production of a PAA-resistant and thermolabile DNA polymerase. PAA1rts1 was also defective in the shutoff of host DNA synthesis at the restrictive temperature.

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Year:  1982        PMID： 6283139      PMCID： PMC256040     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  20 in total

1.  MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY.

Authors:  D R DUBBS; S KIT
Journal:  Virology       Date:  1964-04       Impact factor: 3.616

2.  Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2.

Authors:  P A Schaffer; V C Carter; M C Timbury
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

3.  Genetic and biochemical studies with herpesvirus.

Authors:  J H Subak-Sharpe; S M Brown; D A Ritchie; M C Timbury; J C Macnab; H S Marsden; J Hay
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1975

4.  Genetic and physical evidence for the polarity of transcription of the thymidine kinase gene of herpes simplex virus.

Authors:  J R Smiley; M J Wagner; W P Summers; W C Summers
Journal:  Virology       Date:  1980-04-15       Impact factor: 3.616

5.  Physical and genetic analysis of the herpes simplex virus DNA polymerase locus.

Authors:  P Chartrand; C S Crumpacker; P A Schaffer; N M Wilkie
Journal:  Virology       Date:  1980-06       Impact factor: 3.616

6.  Two types of ribosome in mouse-hamster hybrid cells.

Authors:  C P Stanners; G L Eliceiri; H Green
Journal:  Nat New Biol       Date:  1971-03-10

7.  Physical mapping of paar mutations of herpes simplex virus type 1 and type 2 by intertypic marker rescue.

Authors:  P Chartrand; N D Stow; M C Timbury; N M Wilkie
Journal:  J Virol       Date:  1979-08       Impact factor: 5.103

8.  Genetics of resistance to phosphonoacetic acid in strain KOS of herpes simplex virus type 1.

Authors:  J T Jofre; P A Schaffer; D S Parris
Journal:  J Virol       Date:  1977-09       Impact factor: 5.103

9.  Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2.

Authors:  E D Kieff; S L Bachenheimer; B Roizman
Journal:  J Virol       Date:  1971-08       Impact factor: 5.103

10.  Herpes simplex virus resistance and sensitivity to phosphonoacetic acid.

Authors:  R W Honess; D H Watson
Journal:  J Virol       Date:  1977-02       Impact factor: 5.103
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  2 in total

Review 1.  Recent advances in cloning herpesviral genomes as infectious bacterial artificial chromosomes.

Authors:  Fuchun Zhou; Shou-Jiang Gao
Journal:  Cell Cycle       Date:  2011-02-01       Impact factor: 4.534

2.  Physical mapping of two herpes simplex virus type 1 host shutoff loci: rescue of each ts mutation occurs with two unique cloned regions of the viral genome.

Authors:  J I Daksis; V L Chan
Journal:  J Virol       Date:  1987-01       Impact factor: 5.103
  2 in total

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