OBJECTIVE: To determine if extracorporeal shock wave lithotripsy (ESWL) at 60 shock waves (SWs)/min reduces renal damage and haemodynamic impairment compared to treatment at 120 SWs/min. MATERIALS AND METHODS: One kidney in each of 19 juvenile pigs (7-8 weeks old) was treated at 120 or at 60 SWs/min (2000 SWs, 24 kV) with an unmodified HM-3 lithotripter (Dornier Medical Systems, Kennesaw, GA, USA). Renal function was determined before and after ESWL treatment by inulin clearance, extraction and clearance of para-aminohippuric acid. Both kidneys were then removed to measure parenchymal lesion size by sectioning the entire kidney and quantifying the size of the haemorrhagic lesion in each slice. RESULTS: ESWL at 60 SWs/min significantly reduced the size of the acute morphological lesion compared to 120 SWs/min (0.42% vs 3.93% of functional renal volume, P = 0.011) and blunted the decrease in glomerular filtration rate and renal plasma flow normally seen after treatment at 120 SWs/min. CONCLUSIONS: Treatment at a firing rate of 60 SWs/min produces less morphological injury and causes less alteration in renal haemodynamics than treatment at 120 SWs/min in the pig model of ESWL-induced renal injury.
OBJECTIVE: To determine if extracorporeal shock wave lithotripsy (ESWL) at 60 shock waves (SWs)/min reduces renal damage and haemodynamic impairment compared to treatment at 120 SWs/min. MATERIALS AND METHODS: One kidney in each of 19 juvenile pigs (7-8 weeks old) was treated at 120 or at 60 SWs/min (2000 SWs, 24 kV) with an unmodified HM-3 lithotripter (Dornier Medical Systems, Kennesaw, GA, USA). Renal function was determined before and after ESWL treatment by inulin clearance, extraction and clearance of para-aminohippuric acid. Both kidneys were then removed to measure parenchymal lesion size by sectioning the entire kidney and quantifying the size of the haemorrhagic lesion in each slice. RESULTS: ESWL at 60 SWs/min significantly reduced the size of the acute morphological lesion compared to 120 SWs/min (0.42% vs 3.93% of functional renal volume, P = 0.011) and blunted the decrease in glomerular filtration rate and renal plasma flow normally seen after treatment at 120 SWs/min. CONCLUSIONS: Treatment at a firing rate of 60 SWs/min produces less morphological injury and causes less alteration in renal haemodynamics than treatment at 120 SWs/min in the pig model of ESWL-induced renal injury.
Authors: Bret A Connors; Andrew P Evan; Lynn R Willis; Philip M Blomgren; James E Lingeman; Naomi S Fineberg Journal: J Am Soc Nephrol Date: 2000-02 Impact factor: 10.121
Authors: Amy E Krambeck; Matthew T Gettman; Audrey L Rohlinger; Christine M Lohse; David E Patterson; Joseph W Segura Journal: J Urol Date: 2006-05 Impact factor: 7.450
Authors: Bret A Connors; Ray B Schaefer; John J Gallagher; Cynthia D Johnson; Guangyan Li; Rajash K Handa; Andrew P Evan Journal: Urology Date: 2018-03-27 Impact factor: 2.649
Authors: Rajash K Handa; James A McAteer; Bret A Connors; Ziyue Liu; James E Lingeman; Andrew P Evan Journal: BJU Int Date: 2012-05-22 Impact factor: 5.588
Authors: Bret A Connors; Andrew P Evan; Rajash K Handa; Philip M Blomgren; Cynthia D Johnson; Ziyue Liu; James E Lingeman Journal: J Endourol Date: 2016-07-13 Impact factor: 2.942
Authors: Yuri A Pishchalnikov; James A McAteer; James C Williams; Bret A Connors; Rajash K Handa; James E Lingeman; Andrew P Evan Journal: J Endourol Date: 2013-02-06 Impact factor: 2.942