Literature DB >> 19164211

Providing research results to participants: attitudes and needs of adolescents and parents of children with cancer.

Conrad Vincent Fernandez1, Jun Gao, Caron Strahlendorf, Albert Moghrabi, Rebecca Davis Pentz, Raymond Carlton Barfield, Justin Nathaniel Baker, Darcy Santor, Charles Weijer, Eric Kodish.   

Abstract

PURPOSE: There is an increasing demand for researchers to provide research results to participants. Our aim was to define an appropriate process for this, based on needs and attitudes of participants.
METHODS: A multicenter survey in five sites in the United States and Canada was offered to parents of children with cancer and adolescents with cancer. Respondents indicated their preferred mode of communication of research results with respect to implications; timing, provider, and content of the results; reasons for and against providing results; and barriers to providing results.
RESULTS: Four hundred nine parents (including 19 of deceased children) and 86 adolescents responded. Most parents (n = 385; 94.2%) felt that they had a strong right to research results. For positive results, most wanted a letter or e-mail summary (n = 238; 58.2%) or a phone call followed by a letter (n = 100; 24.4%). If the results were negative, phone call (n = 136; 33.3%) or personal visits (n = 150; 36.7%) were preferred. Parents wanted the summary to include long-term sequelae and suggestions for participants (n = 341; 83.4%), effect on future treatments (n = 341; 83.4%), and subsequent research steps (n = 284; 69.5%). Understanding the researcher was a main concern about receiving results (n = 145; 35.5%). Parents felt that results provide information to support quality of life (n = 315; 77%) and raise public awareness of research (n = 282; 68.9%). Adolescents identified similar preferences.
CONCLUSION: Parents of children with cancer and adolescents with cancer feel strongly that they have a right to be offered research results and have specific preferences of how and what information should be communicated.

Entities:  

Mesh:

Year:  2009        PMID: 19164211      PMCID: PMC2668636          DOI: 10.1200/JCO.2008.18.5223

Source DB:  PubMed          Journal:  J Clin Oncol        ISSN: 0732-183X            Impact factor:   44.544


  31 in total

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Authors:  Zelda Di Blasi; Ted J Kaptchuk; John Weinman; Jos Kleijnen
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2.  Considerations and costs of disclosing study findings to research participants.

Authors:  Conrad V Fernandez; Chris Skedgel; Charles Weijer
Journal:  CMAJ       Date:  2004-04-27       Impact factor: 8.262

3.  Providing research participants with findings from completed cancer-related clinical trials: not quite as simple as it sounds.

Authors:  Maurie Markman
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4.  Thresholds and boundaries in the disclosure of individual genetic research results.

Authors:  Lynn G Dressler; Eric T Juengst
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5.  Informing research participants of research results: analysis of Canadian university based research ethics board policies.

Authors:  S D Macneil; C V Fernandez
Journal:  J Med Ethics       Date:  2006-01       Impact factor: 2.903

6.  Providing research results to study participants: support versus practice of researchers presenting at the American Society of Hematology annual meeting.

Authors:  Heather Rigby; Conrad V Fernandez
Journal:  Blood       Date:  2005-05-05       Impact factor: 22.113

7.  The emergence of an ethical duty to disclose genetic research results: international perspectives.

Authors:  Bartha Maria Knoppers; Yann Joly; Jacques Simard; Francine Durocher
Journal:  Eur J Hum Genet       Date:  2006-07-26       Impact factor: 4.246

8.  Offering to return results to research participants: attitudes and needs of principal investigators in the Children's Oncology Group.

Authors:  Conrad V Fernandez; Eric Kodish; Susan Shurin; Charles Weijer
Journal:  J Pediatr Hematol Oncol       Date:  2003-09       Impact factor: 1.289

9.  Use of the Internet and e-mail for health care information: results from a national survey.

Authors:  Laurence Baker; Todd H Wagner; Sara Singer; M Kate Bundorf
Journal:  JAMA       Date:  2003-05-14       Impact factor: 56.272

10.  Impact on survivors of retinoblastoma when informed of study results on risk of second cancers.

Authors:  Charlene J Schulz; Mary P Riddle; Heiddis B Valdimirsdottir; David H Abramson; Charles A Sklar
Journal:  Med Pediatr Oncol       Date:  2003-07
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  36 in total

1.  Discussing molecular testing in oncology care: Comparing patient and physician information preferences.

Authors:  Ana P M Pinheiro; Rachel H Pocock; Jeffrey M Switchenko; Margie D Dixon; Walid L Shaib; Suresh S Ramalingam; Rebecca D Pentz
Journal:  Cancer       Date:  2017-01-31       Impact factor: 6.860

2.  Disclosure of individualized research results: a precautionary approach.

Authors:  David B Resnik
Journal:  Account Res       Date:  2011-11       Impact factor: 2.622

3.  Utilizing Focus Groups with Potential Participants and Their Parents: An Approach to Inform Study Design in a Large Clinical Trial.

Authors:  Sandeep Kadimpati; Jennifer B McCormick; Yichen Chiu; Ashley B Parker; Aliya Z Iftikhar; Randall P Flick; David O Warner
Journal:  AJOB Empir Bioeth       Date:  2014-01-01

Review 4.  Disclosure of incidental findings from next-generation sequencing in pediatric genomic research.

Authors:  Ruqayyah Abdul-Karim; Benjamin E Berkman; David Wendler; Annette Rid; Javed Khan; Tom Badgett; Sara Chandros Hull
Journal:  Pediatrics       Date:  2013-02-11       Impact factor: 7.124

5.  How Much Control Do Children and Adolescents Have over Genomic Testing, Parental Access to Their Results, and Parental Communication of Those Results to Others?

Authors:  Ellen Wright Clayton
Journal:  J Law Med Ethics       Date:  2015       Impact factor: 1.718

6.  Adolescent perspectives on the return of individual results in genomic addiction research.

Authors:  Marilyn E Coors; Kristen M Raymond; Shannon K McWilliams; Christian J Hopfer; Susan K Mikulich-Gilbertson
Journal:  Psychiatr Genet       Date:  2015-06       Impact factor: 2.458

7.  Communicating the results of research: how do participants of a cardiac rehabilitation RCT prefer to be informed?

Authors:  Hasnain Dalal; Jennifer Wingham; Colin Pritchard; Sharon Northey; Philip Evans; Rod S Taylor; John Campbell
Journal:  Health Expect       Date:  2009-11-10       Impact factor: 3.377

8.  Health research participants' preferences for receiving research results.

Authors:  Christopher R Long; M Kathryn Stewart; Thomas V Cunningham; T Scott Warmack; Pearl A McElfish
Journal:  Clin Trials       Date:  2016-08-24       Impact factor: 2.486

9.  Participants' uptake of clinical trial results: a randomised experiment.

Authors:  J Mancini; D Genre; F Dalenc; J-M Ferrero; P Kerbrat; A-L Martin; H Roché; F Maylevin; C Tarpin; P Viens; J Genève; C Julian-Reynier
Journal:  Br J Cancer       Date:  2010-03-02       Impact factor: 7.640

10.  Recommendations for the return of research results to study participants and guardians: a report from the Children's Oncology Group.

Authors:  Conrad V Fernandez; Kathleen Ruccione; Robert J Wells; Jay B Long; Wendy Pelletier; Mary C Hooke; Rebecca D Pentz; Robert B Noll; Justin N Baker; Maura O'Leary; Gregory Reaman; Peter C Adamson; Steven Joffe
Journal:  J Clin Oncol       Date:  2012-10-29       Impact factor: 44.544

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