Literature DB >> 16048983

Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus.

Nicole Wolter1, Anthony M Smith, David J Farrell, William Schaffner, Matthew Moore, Cynthia G Whitney, James H Jorgensen, Keith P Klugman.   

Abstract

Two clinical Streptococcus pneumoniae isolates, identified as resistant to macrolides and chloramphenicol and nonsusceptible to linezolid, were found to contain 6-bp deletions in the gene encoding riboprotein L4. The gene transformed susceptible strain R6 so that it exhibited such resistance, with the transformants also showing a fitness cost. We demonstrate a novel bacterial mechanism of resistance to chloramphenicol and nonsusceptibility to linezolid.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16048983      PMCID： PMC1196237          DOI： 10.1128/AAC.49.8.3554-3557.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  34 in total

Review 1.  Antibiotic resistance in the absence of selective pressure.

Authors:  S H Gillespie
Journal:  Int J Antimicrob Agents       Date:  2001-03       Impact factor: 5.283

2.  Serotype 19f multiresistant pneumococcal clone harboring two erythromycin resistance determinants (erm(B) and mef(A)) in South Africa.

Authors:  L McGee; K P Klugman; A Wasas; T Capper; A Brink
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

3.  REGULATION OF THE TRANSFORMABILITY OF PHEUMOCOCCAL CULTURES BY MACROMOLECULAR CELL PRODUCTS.

Authors:  A TOMASZ; R D HOTCHKISS
Journal:  Proc Natl Acad Sci U S A       Date:  1964-03       Impact factor: 11.205

4.  Non-Penicillin-Binding protein mediated high-level penicillin and cephalosporin resistance in a Hungarian clone of Streptococcus pneumoniae.

Authors:  A M Smith; K P Klugman
Journal:  Microb Drug Resist       Date:  2000       Impact factor: 3.431

5.  Linezolid resistance in a clinical isolate of Staphylococcus aureus.

Authors:  S Tsiodras; H S Gold; G Sakoulas; G M Eliopoulos; C Wennersten; L Venkataraman; R C Moellering; M J Ferraro
Journal:  Lancet       Date:  2001-07-21       Impact factor: 79.321

6.  Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci.

Authors:  J Prystowsky; F Siddiqui; J Chosay; D L Shinabarger; J Millichap; L R Peterson; G A Noskin
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

7.  Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.

Authors:  P Kloss; L Xiong; D L Shinabarger; A S Mankin
Journal:  J Mol Biol       Date:  1999-11-19       Impact factor: 5.469

8.  Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

Authors:  L Xiong; P Kloss; S Douthwaite; N M Andersen; S Swaney; D L Shinabarger; A S Mankin
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

9.  Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage.

Authors:  A Tait-Kamradt; T Davies; M Cronan; M R Jacobs; P C Appelbaum; J Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  2000-08       Impact factor: 5.191

10.  Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America.

Authors:  A Tait-Kamradt; T Davies; P C Appelbaum; F Depardieu; P Courvalin; J Petitpas; L Wondrack; A Walker; M R Jacobs; J Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191
View more
  55 in total

Review 1.  Resistance to linezolid caused by modifications at its binding site on the ribosome.

Authors:  Katherine S Long; Birte Vester
Journal:  Antimicrob Agents Chemother       Date:  2011-12-05       Impact factor: 5.191

Review 2.  Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.

Authors:  Barbara A Brown-Elliott; Kevin A Nash; Richard J Wallace
Journal:  Clin Microbiol Rev       Date:  2012-07       Impact factor: 26.132

3.  Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.

Authors:  Katherine S Long; Christian Munck; Theis M B Andersen; Maria A Schaub; Sven N Hobbie; Erik C Böttger; Birte Vester
Journal:  Antimicrob Agents Chemother       Date:  2010-08-09       Impact factor: 5.191

4.  Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene.

Authors:  Jeffrey B Locke; Douglas E Zuill; Caitlyn R Scharn; Jennifer Deane; Daniel F Sahm; Gerald A Denys; Richard V Goering; Karen J Shaw
Journal:  Antimicrob Agents Chemother       Date:  2014-08-25       Impact factor: 5.191

5.  Heterogeneous macrolide resistance and gene conversion in the pneumococcus.

Authors:  Nicole Wolter; Anthony M Smith; David J Farrell; Keith P Klugman
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

6.  In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens.

Authors:  Laura Lawrence; Paul Danese; Joe DeVito; Francois Franceschi; Joyce Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  2008-03-03       Impact factor: 5.191

7.  Evaluating aztreonam and ceftazidime pharmacodynamics with Escherichia coli in combination with daptomycin, linezolid, or vancomycin in an in vitro pharmacodynamic model.

Authors:  Kerry L LaPlante; George Sakoulas
Journal:  Antimicrob Agents Chemother       Date:  2009-07-20       Impact factor: 5.191

8.  Effects on translation pausing of alterations in protein and RNA components of the ribosome exit tunnel.

Authors:  Marlon G Lawrence; Lasse Lindahl; Janice M Zengel
Journal:  J Bacteriol       Date:  2008-06-27       Impact factor: 3.490

9.  Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus.

Authors:  Yurika Ikeda-Dantsuji; Hideaki Hanaki; Taiji Nakae; Yoshio Takesue; Kazunori Tomono; Junichi Honda; Katsunori Yanagihara; Hiroshige Mikamo; Kunihiko Fukuchi; Mitsuo Kaku; Shigeru Kohno; Yoshihito Niki
Journal:  Antimicrob Agents Chemother       Date:  2011-02-28       Impact factor: 5.191

10.  Outbreak of linezolid-resistant Staphylococcus haemolyticus in an Italian intensive care unit.

Authors:  A Mazzariol; G Lo Cascio; E Kocsis; L Maccacaro; R Fontana; G Cornaglia
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-07-27       Impact factor: 3.267
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.