Literature DB >> 11302838

Serotype 19f multiresistant pneumococcal clone harboring two erythromycin resistance determinants (erm(B) and mef(A)) in South Africa.

L McGee1, K P Klugman, A Wasas, T Capper, A Brink.   

Abstract

One hundred eighteen erythromycin-resistant Streptococcus pneumoniae (ERSP) strains (MICs of > or = 0.5 microg/ml) from five laboratories serving the private sector in South Africa were analyzed for the genes encoding resistance to macrolides. Sixty-seven ERSP strains (56.8%) contained the erm(B) gene, and 15 isolates (12.7%) contained the mef(A) gene. Thirty-six isolates (30.5%) harbored both the erm(B) and mef(A) genes and were highly resistant to erythromycin and clindamycin. DNA fingerprinting by BOX-PCR and pulsed-field gel electrophoresis identified 83% of these strains as belonging to a single multiresistant serotype 19F clone.

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Year:  2001        PMID： 11302838      PMCID： PMC90516          DOI： 10.1128/AAC.45.5.1595-1598.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

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Authors:  M C Roberts; J Sutcliffe; P Courvalin; L B Jensen; J Rood; H Seppala
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

2.  A variety of gram-positive bacteria carry mobile mef genes.

Authors:  V A Luna; P Coates; E A Eady; J H Cove; T T Nguyen; M C Roberts
Journal:  J Antimicrob Chemother       Date:  1999-07       Impact factor: 5.790

3.  Prevalence and characterization of the mechanisms of macrolide, lincosamide, and streptogramin resistance in isolates of Streptococcus pneumoniae.

Authors:  N J Johnston; J C De Azavedo; J D Kellner; D E Low
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

4.  Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study.

Authors:  G V Doern; A Brueggemann; H P Holley; A M Rauch
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

5.  Distribution of mefE and ermB genes in macrolide-resistant strains of Streptococcus pneumoniae and their variable susceptibility to various antibiotics.

Authors:  T Nishijima; Y Saito; A Aoki; M Toriya; Y Toyonaga; R Fujii
Journal:  J Antimicrob Chemother       Date:  1999-05       Impact factor: 5.790

6.  Differential subsequence conservation of interspersed repetitive Streptococcus pneumoniae BOX elements in diverse bacteria.

Authors:  T Koeuth; J Versalovic; J R Lupski
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Authors:  A Tait-Kamradt; J Clancy; M Cronan; F Dib-Hajj; L Wondrack; W Yuan; J Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

8.  Molecular characterization of penicillin-resistant Streptococcus pneumoniae isolates causing respiratory disease in the United States.

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Journal:  Microb Drug Resist       Date:  1998       Impact factor: 3.431

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Authors:  S L Kaplan; E O Mason
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10.  Emergence of the M phenotype of erythromycin-resistant pneumococci in South Africa.

Authors:  C A Widdowson; K P Klugman
Journal:  Emerg Infect Dis       Date:  1998 Apr-Jun       Impact factor: 6.883
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  31 in total

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3.  Resistance phenotypes and genotypes of erythromycin-resistant Streptococcus pneumoniae isolates in Beijing and Shenyang, China.

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Journal:  J Clin Microbiol       Date:  2004-11       Impact factor: 5.948

5.  Prevalence and molecular genetics of macrolide resistance among Streptococcus pneumoniae isolates collected in Finland in 2002.

Authors:  M Rantala; S Huikko; P Huovinen; J Jalava
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Review 6.  Molecular detection of the macrolide efflux gene: to discriminate or not to discriminate between mef(A) and mef(E).

Authors:  Corné H W Klaassen; Johan W Mouton
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

7.  Heterogeneous macrolide resistance and gene conversion in the pneumococcus.

Authors:  Nicole Wolter; Anthony M Smith; David J Farrell; Keith P Klugman
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

8.  Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus.

Authors:  Nicole Wolter; Anthony M Smith; David J Farrell; William Schaffner; Matthew Moore; Cynthia G Whitney; James H Jorgensen; Keith P Klugman
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9.  The macrolide resistance genes erm(B) and mef(E) are carried by Tn2010 in dual-gene Streptococcus pneumoniae isolates belonging to clonal complex CC271.

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