Literature DB >> 21357291

Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus.

Yurika Ikeda-Dantsuji1, Hideaki Hanaki, Taiji Nakae, Yoshio Takesue, Kazunori Tomono, Junichi Honda, Katsunori Yanagihara, Hiroshige Mikamo, Kunihiko Fukuchi, Mitsuo Kaku, Shigeru Kohno, Yoshihito Niki.   

Abstract

Methicillin-resistant Staphylococcus aureus with a MIC of linezolid of 4 μg/ml, isolated from a patient who had undergone unsuccessful linezolid therapy, yielded linezolid-resistant mutants in blood agar at 48 h of incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 μg/ml and accumulated the T2500A mutation(s) of the rRNA genes. Emergence of these resistant clones appears to be facilitated by a cryptic mutation or mutations associated with chloramphenicol resistance.

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Year:  2011        PMID： 21357291      PMCID： PMC3088184          DOI： 10.1128/AAC.01548-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Linezolid resistance in clinical isolates of Staphylococcus aureus.

Authors:  Peter Wilson; J A Andrews; R Charlesworth; R Walesby; M Singer; D J Farrell; M Robbins
Journal:  J Antimicrob Chemother       Date:  2003-01       Impact factor: 5.790

2.  Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus.

Authors:  Nicole Wolter; Anthony M Smith; David J Farrell; William Schaffner; Matthew Moore; Cynthia G Whitney; James H Jorgensen; Keith P Klugman
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

3.  Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances.

Authors:  Silke Besier; Albrecht Ludwig; Johannes Zander; Volker Brade; Thomas A Wichelhaus
Journal:  Antimicrob Agents Chemother       Date:  2008-01-22       Impact factor: 5.191

4.  Linezolid-resistant Staphylococcus aureus isolated from 2006 through 2008 at six hospitals in Japan.

Authors:  Yurika Ikeda-Dantsuji; Hideaki Hanaki; Fuminori Sakai; Kazunori Tomono; Yoshio Takesue; Junichi Honda; Yuriko Nonomiya; Akira Suwabe; Osanori Nagura; Katsunori Yanagihara; Hiroshige Mikamo; Kunihiko Fukuchi; Mitsuo Kaku; Shigeru Kohno; Chie Yanagisawa; Taiji Nakae; Koichiro Yoshida; Yoshihito Niki
Journal:  J Infect Chemother       Date:  2010-07-07       Impact factor: 2.211

5.  Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype.

Authors:  Satish K Pillai; George Sakoulas; Christine Wennersten; George M Eliopoulos; Robert C Moellering; Mary Jane Ferraro; Howard S Gold
Journal:  J Infect Dis       Date:  2002-11-04       Impact factor: 5.226

6.  Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).

Authors:  Jeffrey B Locke; Mark Hilgers; Karen Joy Shaw
Journal:  Antimicrob Agents Chemother       Date:  2009-09-14       Impact factor: 5.191

7.  Clinical and microbiological aspects of linezolid resistance mediated by the cfr gene encoding a 23S rRNA methyltransferase.

Authors:  Cesar A Arias; Martha Vallejo; Jinnethe Reyes; Diana Panesso; Jaime Moreno; Elizabeth Castañeda; Maria V Villegas; Barbara E Murray; John P Quinn
Journal:  J Clin Microbiol       Date:  2008-01-03       Impact factor: 5.948

Review 8.  Oxazolidinones: activity, mode of action, and mechanism of resistance.

Authors:  Bülent Bozdogan; Peter C Appelbaum
Journal:  Int J Antimicrob Agents       Date:  2004-02       Impact factor: 5.283

9.  Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid.

Authors:  Seok-Ming Toh; Liqun Xiong; Cesar A Arias; Maria V Villegas; Karen Lolans; John Quinn; Alexander S Mankin
Journal:  Mol Microbiol       Date:  2007-06       Impact factor: 3.501

10.  Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.

Authors:  Venkata G Meka; Satish K Pillai; George Sakoulas; Christine Wennersten; Lata Venkataraman; Paola C DeGirolami; George M Eliopoulos; Robert C Moellering; Howard S Gold
Journal:  J Infect Dis       Date:  2004-06-09       Impact factor: 5.226
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  7 in total

1.  TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.

Authors:  Malvika Kaul; Lilly Mark; Yongzheng Zhang; Ajit K Parhi; Yi Lisa Lyu; Joan Pawlak; Stephanie Saravolatz; Louis D Saravolatz; Melvin P Weinstein; Edmond J LaVoie; Daniel S Pilch
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

2.  Antibiotic Practice Change to Curtail Linezolid Use in Pediatric Hospitalized Patients in Hawai'i with Uncomplicated Skin and Soft Tissue Infections.

Authors:  Cheryl Okado; Tori Teramae
Journal:  Hawaii J Health Soc Welf       Date:  2020-05-01

3.  In vitro resistance studies with bacteria that exhibit low mutation frequencies: prediction of "antimutant" linezolid concentrations using a mixed inoculum containing both susceptible and resistant Staphylococcus aureus.

Authors:  Alexander A Firsov; Maria V Golikova; Elena N Strukova; Yury A Portnoy; Andrey V Romanov; Mikhail V Edelstein; Stephen H Zinner
Journal:  Antimicrob Agents Chemother       Date:  2014-12-01       Impact factor: 5.191

4.  Comparison of In-vitro Activities of Linezolid and Vancomycin against Staphylococcus aureus Isolated from A Tertiary Care Hospital.

Authors:  Sachin Kishore; Deepika Verma; Me Siddique
Journal:  J Clin Diagn Res       Date:  2014-05-15

Review 5.  Vaccines Against Antimicrobial Resistance.

Authors:  Roberto Rosini; Sonia Nicchi; Mariagrazia Pizza; Rino Rappuoli
Journal:  Front Immunol       Date:  2020-06-03       Impact factor: 7.561

6.  Ultrastructural changes in methicillin-resistant Staphylococcus aureus induced by positively charged silver nanoparticles.

Authors:  Dulce G Romero-Urbina; Humberto H Lara; J Jesús Velázquez-Salazar; M Josefina Arellano-Jiménez; Eduardo Larios; Anand Srinivasan; Jose L Lopez-Ribot; Miguel José Yacamán
Journal:  Beilstein J Nanotechnol       Date:  2015-12-15       Impact factor: 3.649

7.  Design and Preclinical Development of a Phage Product for the Treatment of Antibiotic-Resistant Staphylococcus aureus Infections.

Authors:  Susan M Lehman; Gillian Mearns; Deborah Rankin; Robert A Cole; Frenk Smrekar; Steven D Branston; Sandra Morales
Journal:  Viruses       Date:  2019-01-21       Impact factor: 5.048
  7 in total

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