| Literature DB >> 19620335 |
Kerry L LaPlante1, George Sakoulas.
Abstract
In an in vitro pharmacodynamic model, linezolid attenuated the activity of aztreonam and ceftazidime against Escherichia coli. Conversely, synergy was detected at 24 and 48 h when daptomycin or vancomycin was added to aztreonam and ceftazidime. We conclude that significant yet underappreciated interactions may occur between gram-positive-spectrum and gram-negative-spectrum antibacterials.Entities:
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Year: 2009 PMID: 19620335 PMCID: PMC2764192 DOI: 10.1128/AAC.00180-09
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191