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Literature DB >> 21792559

Outbreak of linezolid-resistant Staphylococcus haemolyticus in an Italian intensive care unit.

A Mazzariol¹, G Lo Cascio, E Kocsis, L Maccacaro, R Fontana, G Cornaglia.

Abstract

We report an outbreak of linezolid-resistant Staphylococcus haemolyticus strains (MIC 32 mg/L) in patients admitted to the Verona University Hospital Intensive Care Unit. The strains proved to be clonally related at pulsed field gel electrophoresis. All the strains showed the G2576T mutation responsible for linezolid-resistance and retained their resistance even after several passages on antibiotic-free medium. After a decade of linezolid use, multifocal emergence of linezolid resistance in coagulase-negative staphylococci has become an important matter of concern and mandates stricter control over the use of this antibiotic in order to preserve its clinical utility.

Entities: Chemical Mutation Species

Mesh：

Substances：

Year: 2011 PMID： 21792559 DOI： 10.1007/s10096-011-1343-6

Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN： 0934-9723 Impact factor: 3.267

20 in total

1. Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis.

Authors: S H Marshall; C J Donskey; R Hutton-Thomas; R A Salata; L B Rice
Journal: Antimicrob Agents Chemother Date: 2002-10 Impact factor: 5.191

2. First report of Staphylococcal clinical isolates in Mexico with linezolid resistance caused by cfr: evidence of in vivo cfr mobilization.

Authors: Rodrigo E Mendes; Lalitagauri Deshpande; Eduardo Rodriguez-Noriega; James E Ross; Ronald N Jones; Rayo Morfin-Otero
Journal: J Clin Microbiol Date: 2010-06-02 Impact factor: 5.948

3. Linezolid resistance in coagulase-negative staphylococci.

Authors: S Kelly; J Collins; M Davin; C Gowing; P G Murphy
Journal: J Antimicrob Chemother Date: 2006-07-19 Impact factor: 5.790

4. Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates.

Authors: Corinna Kehrenberg; Stefan Schwarz
Journal: Antimicrob Agents Chemother Date: 2006-04 Impact factor: 5.191

5. DNA methylase modifications and other linezolid resistance mutations in coagulase-negative staphylococci in Italy.

Authors: Dafne Bongiorno; Floriana Campanile; Gino Mongelli; Maria Teresa Baldi; Rosamaria Provenzani; Silvia Reali; Carolina Lo Russo; Maria Santagati; Stefania Stefani
Journal: J Antimicrob Chemother Date: 2010-09-18 Impact factor: 5.790

6. Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.

Authors: Fumihiko Takeuchi; Shinya Watanabe; Tadashi Baba; Harumi Yuzawa; Teruyo Ito; Yuh Morimoto; Makoto Kuroda; Longzhu Cui; Mikio Takahashi; Akiho Ankai; Shin-ichi Baba; Shigehiro Fukui; Jean C Lee; Keiichi Hiramatsu
Journal: J Bacteriol Date: 2005-11 Impact factor: 3.490

7. Polyphyletic emergence of linezolid-resistant staphylococci in the United States.

Authors: Agnes Wong; Shilpa P Reddy; Davida S Smyth; Maria E Aguero-Rosenfeld; George Sakoulas; D Ashley Robinson
Journal: Antimicrob Agents Chemother Date: 2009-11-23 Impact factor: 5.191

8. Antimicrobial resistance in nosocomial isolates of Staphylococcus haemolyticus.

Authors: J W Froggatt; J L Johnston; D W Galetto; G L Archer
Journal: Antimicrob Agents Chemother Date: 1989-04 Impact factor: 5.191

9. Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.

Authors: Jeffrey B Locke; Mark Hilgers; Karen Joy Shaw
Journal: Antimicrob Agents Chemother Date: 2009-10-05 Impact factor: 5.191

10. Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.

Authors: Venkata G Meka; Satish K Pillai; George Sakoulas; Christine Wennersten; Lata Venkataraman; Paola C DeGirolami; George M Eliopoulos; Robert C Moellering; Howard S Gold
Journal: J Infect Dis Date: 2004-06-09 Impact factor: 5.226

10 in total

1. Clonal dissemination of linezolid-resistant Staphylococcus haemolyticus exhibiting the G2576T mutation in the 23S rRNA gene in a tertiary care hospital in Brazil.

Authors: Lara M de Almeida; Nilton Lincopan; Maria Rita E de Araújo; Elsa M Mamizuka
Journal: Antimicrob Agents Chemother Date: 2012-02-06 Impact factor: 5.191

Review 2. Coagulase-negative staphylococci.

Authors: Karsten Becker; Christine Heilmann; Georg Peters
Journal: Clin Microbiol Rev Date: 2014-10 Impact factor: 26.132

Review 3. Clinical Infections, Antibiotic Resistance, and Pathogenesis of Staphylococcus haemolyticus.

Authors: Hala O Eltwisy; Howida Omar Twisy; Mahmoud Hr Hafez; Ibrahim M Sayed; Mohamed A El-Mokhtar
Journal: Microorganisms Date: 2022-05-31

4. Emergence of cfr-Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with Cystic Fibrosis.

Authors: Juan de Dios Caballero; María Dolores Pastor; Ana Vindel; Luis Máiz; Genoveva Yagüe; Carme Salvador; Marta Cobo; María-Isabel Morosini; Rosa del Campo; Rafael Cantón
Journal: Antimicrob Agents Chemother Date: 2015-12-14 Impact factor: 5.191

5. Staphylococcus haemolyticus strains target mitochondria and induce caspase-dependent apoptosis of macrophages.

Authors: Sylwia Krzymińska; Ewa Szczuka; Adam Kaznowski
Journal: Antonie Van Leeuwenhoek Date: 2012-06-02 Impact factor: 2.271

6. Diversity of staphylococcal cassette chromosome mec elements in nosocomial multiresistant Staphylococcus haemolyticus isolates.

Authors: Ewa Szczuka; Magdalena Krajewska; Dagmara Lijewska; Karolina Bosacka; Adam Kaznowski
Journal: J Appl Genet Date: 2016-04-07 Impact factor: 3.240

7. Polyvalent Phage CoNShP-3 as a Natural Antimicrobial Agent Showing Lytic and Antibiofilm Activities against Antibiotic-Resistant Coagulase-Negative Staphylococci Strains.

Authors: Ahmed R Sofy; Naglaa F Abd El Haliem; Ehab E Refaey; Ahmed A Hmed
Journal: Foods Date: 2020-05-23