Literature DB >> 15187180

A new biology for a new century.

Carl R Woese1.   

Abstract

Biology today is at a crossroads. The molecular paradigm, which so successfully guided the discipline throughout most of the 20th century, is no longer a reliable guide. Its vision of biology now realized, the molecular paradigm has run its course. Biology, therefore, has a choice to make, between the comfortable path of continuing to follow molecular biology's lead or the more invigorating one of seeking a new and inspiring vision of the living world, one that addresses the major problems in biology that 20th century biology, molecular biology, could not handle and, so, avoided. The former course, though highly productive, is certain to turn biology into an engineering discipline. The latter holds the promise of making biology an even more fundamental science, one that, along with physics, probes and defines the nature of reality. This is a choice between a biology that solely does society's bidding and a biology that is society's teacher.

Mesh:

Year:  2004        PMID: 15187180      PMCID: PMC419918          DOI: 10.1128/MMBR.68.2.173-186.2004

Source DB:  PubMed          Journal:  Microbiol Mol Biol Rev        ISSN: 1092-2172            Impact factor:   11.056


  36 in total

Review 1.  Translation: in retrospect and prospect.

Authors:  C R Woese
Journal:  RNA       Date:  2001-08       Impact factor: 4.942

2.  Structural biology. The ribosome is a ribozyme.

Authors:  T R Cech
Journal:  Science       Date:  2000-08-11       Impact factor: 47.728

3.  THE "DELFT SCHOOL" AND THE RISE OF GENERAL MICROBIOLOGY.

Authors:  C B Van Niel
Journal:  Bacteriol Rev       Date:  1949-09

4.  THE RELATIONSHIP BETWEEN BACTERIA AND MYXOPHYCEAE.

Authors:  E G Pringsheim
Journal:  Bacteriol Rev       Date:  1949-06

5.  The universal ancestor.

Authors:  C Woese
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205

6.  From replicators to reproducers: the first major transitions leading to life.

Authors:  E Szathmáry; J Maynard Smith
Journal:  J Theor Biol       Date:  1997-08-21       Impact factor: 2.691

7.  Phylogenetic structure of the prokaryotic domain: the primary kingdoms.

Authors:  C R Woese; G E Fox
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

8.  Molecular mechanics of translation: a reciprocating ratchet mechanism.

Authors:  C Woese
Journal:  Nature       Date:  1970-05-30       Impact factor: 49.962

9.  The phylogeny of prokaryotes.

Authors:  G E Fox; E Stackebrandt; R B Hespell; J Gibson; J Maniloff; T A Dyer; R S Wolfe; W E Balch; R S Tanner; L J Magrum; L B Zablen; R Blakemore; R Gupta; L Bonen; B J Lewis; D A Stahl; K R Luehrsen; K N Chen; C R Woese
Journal:  Science       Date:  1980-07-25       Impact factor: 47.728

10.  Are extreme halophiles actually "bacteria"?

Authors:  L J Magrum; K R Luehrsen; C R Woese
Journal:  J Mol Evol       Date:  1978-05-12       Impact factor: 2.395

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  79 in total

Review 1.  The driving force for molecular evolution of translation.

Authors:  Harry F Noller
Journal:  RNA       Date:  2004-12       Impact factor: 4.942

2.  Phylogeny and beyond: Scientific, historical, and conceptual significance of the first tree of life.

Authors:  Norman R Pace; Jan Sapp; Nigel Goldenfeld
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-17       Impact factor: 11.205

3.  Comparison of large-insert, small-insert and pyrosequencing libraries for metagenomic analysis.

Authors:  Thomas Danhorn; Curtis R Young; Edward F DeLong
Journal:  ISME J       Date:  2012-04-26       Impact factor: 10.302

4.  Stigmergic gene transfer and emergence of universal coding.

Authors:  Mikhail Prokopenko; Daniel Polani; Matthew Chadwick
Journal:  HFSP J       Date:  2009-08-06

Review 5.  Archaea--timeline of the third domain.

Authors:  Ricardo Cavicchioli
Journal:  Nat Rev Microbiol       Date:  2010-12-06       Impact factor: 60.633

Review 6.  Setting the stage: the history, chemistry, and geobiology behind RNA.

Authors:  Steven A Benner; Hyo-Joong Kim; Zunyi Yang
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-01-01       Impact factor: 10.005

7.  Synthetic consciousness: the distributed adaptive control perspective.

Authors:  Paul F M J Verschure
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-08-19       Impact factor: 6.237

Review 8.  Molecules into cells: specifying spatial architecture.

Authors:  Franklin M Harold
Journal:  Microbiol Mol Biol Rev       Date:  2005-12       Impact factor: 11.056

9.  Complex adaptive system models and the genetic analysis of plasma HDL-cholesterol concentration.

Authors:  Thomas J Rea; Christine M Brown; Charles F Sing
Journal:  Perspect Biol Med       Date:  2006       Impact factor: 1.416

10.  Pattern pluralism and the Tree of Life hypothesis.

Authors:  W Ford Doolittle; Eric Bapteste
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-29       Impact factor: 11.205

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