New methods for fast multidimensional NMR.

Considerable excitement has been aroused by recent new methods for speeding up multidimensional NMR experiments by radically modifying the normal time-domain sampling protocols. These new schemes include the filter diagonalization method, GFT-NMR, the single-scan two-dimensional technique, Hadamard spectroscopy, and a proposal based on projection-reconstruction of three-dimensional spectra. All these methods deliver appreciable improvements in the speed of data acquisition and show promise for speeding up multidimensional NMR of proteins. This perspective aims to describe these important new procedures in simple terms and to comment on their advantages and possible limitations.