Literature DB >> 9836626

Synthesis of imidazo[1,2-a]pyridines as antiviral agents.

A Gueiffier1, S Mavel, M Lhassani, A Elhakmaoui, R Snoeck, G Andrei, O Chavignon, J C Teulade, M Witvrouw, J Balzarini, E De Clercq, J P Chapat.   

Abstract

The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9836626     DOI： 10.1021/jm981051y

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  14 in total

Review 1.  Recent progress of isocyanide-based multicomponent reactions in Iran.

Authors:  Ahmad Shaabani; Ali Maleki; Ali Hossein Rezayan; Afshin Sarvary
Journal:  Mol Divers       Date:  2010-07-29       Impact factor: 2.943

2.  6-Benzyl-3,4-dimeth-oxy-10-methyl-pyrido[2',1':2,3]imidazo[4,5-c]isoquinolin-5(6H)-one.

Authors:  Kathrin Meindl; Daniel Stern; Fadime Mert-Balci; Uwe Beifuss
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-09-12

3.  Gold Catalysed Redox Synthesis of Imidazo[1,2-a]pyridine using Pyridine N-Oxide and Alkynes.

Authors:  Eric P A Talbot; Melodie Richardson; Jeffrey M McKenna; F Dean Toste
Journal:  Adv Synth Catal       Date:  2014-03-10       Impact factor: 5.837

4.  Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.

Authors:  Ananda Herath; Russell Dahl; Nicholas D P Cosford
Journal:  Org Lett       Date:  2010-02-05       Impact factor: 6.005

5.  2-Amino-5-nitro-pyridinium tri-fluoro-acetate.

Authors:  Josephine Viavulamary Jovita; Shanmugam Sathya; Govindasamy Usha; Ramachandran Vasanthi; Krishnan Sarada Ezhilarasi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-11

6.  N-(2-Phenyl-imidazo[1,2-a]pyridin-3-yl)acetamide.

Authors:  Abderrahmane Anaflous; Hanane Albay; Nour-Eddine Benchat; Brahim El Bali; Michal Dušek; Karla Fejfarová
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-04-26

7.  Ethyl 8-amino-6-bromoimidazo[1,2-a]pyridine-2-carb-oxy-late.

Authors:  Siham Dahmani; Youssef Kandri Rodi; Santiago V Luis; El Mokhtar Essassi; Lahcen El Ammari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-05-11

8.  Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Authors:  Lisa Yu; Andres Lopez; Abderrahmane Anaflous; Brahim El Bali; Abdellah Hamal; Elke Ericson; Lawrence E Heisler; Angus McQuibban; Guri Giaever; Corey Nislow; Charles Boone; Grant W Brown; Mohammed Bellaoui
Journal:  PLoS Genet       Date:  2008-11-28       Impact factor: 5.917

9.  Microwave assisted synthesis of bis and tris(ω-bromoacetophenones): versatile precursors for novel bis(imidazo[1,2-a]pyridines), bis(imidazo[1,2-a]pyrimidines) and their tris-analogs.

Authors:  Mohamed R Shaaban
Journal:  Chem Cent J       Date:  2013-06-19       Impact factor: 4.215

10.  A novel class of extended pi-conjugated systems: one-pot synthesis of bis-3-aminoimidazo[1,2-a]pyridines, pyrimidines and pyrazines.

Authors:  Ahmad Shaabani; Ebrahim Soleimani; Ali Maleki; Jafar Moghimi-Rad
Journal:  Mol Divers       Date:  2008-12-02       Impact factor: 3.364
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.