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Literature DB >> 19048381

A novel class of extended pi-conjugated systems: one-pot synthesis of bis-3-aminoimidazo[1,2-a]pyridines, pyrimidines and pyrazines.

Ahmad Shaabani¹, Ebrahim Soleimani, Ali Maleki, Jafar Moghimi-Rad.

Abstract

Bis-3-aminoimidazo[1, 2-a] pyridines, pyrimidines and pyrazines as extended pi-conjugated systems were synthesized for the first time by a novel pseudo five-component condensation of 2-aminopyridine pyrimidines and pyrazines derivatives with terephthalaldehyde or isoph-thalaldehyde and isocyanides in the presence of p-toluene-sulfonic acid in methanol.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 19048381 DOI： 10.1007/s11030-008-9101-0

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 3.364

13 in total

1. Maximizing synthetic efficiency: multi-component transformations lead the way

Authors:
Journal: Chemistry Date: 2000-09-15 Impact factor: 5.236

2. Multicomponent Reactions with Isocyanides.

Authors:
Journal: Angew Chem Int Ed Engl Date: 2000-09-15 Impact factor: 15.336

Review 3. "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.

Authors: Christopher Hulme; Vijay Gore
Journal: Curr Med Chem Date: 2003-01 Impact factor: 4.530

Review 4. Recent developments in isocyanide based multicomponent reactions in applied chemistry.

Authors: Alexander Dömling
Journal: Chem Rev Date: 2006-01 Impact factor: 60.622

5. A novel isocyanide-based three-component reaction: synthesis of highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives.

Authors: Ahmad Shaabani; Ali Maleki; Jafar Moghimi-Rad
Journal: J Org Chem Date: 2007-07-04 Impact factor: 4.354

6. Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type.

Authors: G Trapani; M Franco; L Ricciardi; A Latrofa; G Genchi; E Sanna; F Tuveri; E Cagetti; G Biggio; G Liso
Journal: J Med Chem Date: 1997-09-12 Impact factor: 7.446

7. 2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imid azo[1,2-a]pyridines as a novel class of inhibitors of human rhinovirus: stereospecific synthesis and antiviral activity.

Authors: C Hamdouchi; J de Blas; M del Prado; J Gruber; B A Heinz; L Vance
Journal: J Med Chem Date: 1999-01-14 Impact factor: 7.446

2. Ammonium chloride-catalyzed green multicomponent synthesis of dihydropyrazine and tetrahydrodiazepine derivatives "on water".

Authors: Ahmad Shaabani; Heshmatollah Sepahvand; Shima Ghasemi
Journal: Mol Divers Date: 2018-11-21 Impact factor: 2.943

2 in total

A novel class of extended pi-conjugated systems: one-pot synthesis of bis-3-aminoimidazo[1,2-a]pyridines, pyrimidines and pyrazines.

1. Maximizing synthetic efficiency: multi-component transformations lead the way

2. Multicomponent Reactions with Isocyanides.

Review 3. "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.

Review 4. Recent developments in isocyanide based multicomponent reactions in applied chemistry.

5. A novel isocyanide-based three-component reaction: synthesis of highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives.

6. Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type.

7. 2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imid azo[1,2-a]pyridines as a novel class of inhibitors of human rhinovirus: stereospecific synthesis and antiviral activity.

8. A novel one-pot pseudo-five-component synthesis of 4,5,6,7-tetrahydro-1H-1,4-diazepine-5-carboxamide derivatives.

9. Novel multicomponent one-pot synthesis of tetrahydro-1H-1,5-benzodiazepine-2-carboxamide derivatives.

10. A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles.

Review 1. Recent progress of isocyanide-based multicomponent reactions in Iran.

2. Ammonium chloride-catalyzed green multicomponent synthesis of dihydropyrazine and tetrahydrodiazepine derivatives "on water".