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Literature DB >> 20038130

Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.

Ananda Herath¹, Russell Dahl, Nicholas D P Cosford.

Abstract

The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates.

Entities: Chemical Disease Gene

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Year: 2010 PMID： 20038130 PMCID： PMC2814065 DOI： 10.1021/ol902433a

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

50 in total

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