Literature DB >> 9459008

Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives.

J C Lien1, L J Huang, J P Wang, C M Teng, K H Lee, S C Kuo.   

Abstract

A series of 2-substituted 3-chloro-1,4-naphthoquinones was synthesized, and the antiplatelet, antiinflammatory, and antiallergic activities of these compounds were evaluated. The structure-activity relationships in this series were also examined. Most of the 2-alkyl/arylcarboxamido derivatives of 3-chloro-1,4-naphthoquinone showed potent activities with similar trends in each of the activities evaluated.

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Year:  1997        PMID： 9459008     DOI： 10.1016/s0968-0896(97)00133-8

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  10 in total

1.  Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma.

Authors:  Ashraf A Aly; Essmat M El-Sheref; Momtaz E M Bakheet; Mai A E Mourad; Stefan Bräse; Mahmoud A A Ibrahim; Martin Nieger; Boyan K Garvalov; Kevin N Dalby; Tamer S Kaoud
Journal:  Bioorg Chem       Date:  2018-10-23       Impact factor: 5.275

2.  N-(3-Bromo-1,4-dioxo-1,4-dihydro-2-naphth-yl)-4-fluoro-N-(4-fluoro-benzo-yl)benzamide.

Authors:  Emmanuel S Akinboye; Ray J Butcher; Dwayne A Wright; Yakini Brandy; Oladapo Bakare
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-10

3.  N-(3-Bromo-1,4-dioxo-1,4-dihydro-2-naphth-yl)-2-chloro-N-(2-chloro-benzoyl)benzamide.

Authors:  Emmanuel S Akinboye; Ray J Butcher; Yakini Brandy; Tolulope A Adesiyun; Oladapo Bakare
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-12-06

4.  Comprehensive evaluation of a novel nuclear factor-kappaB inhibitor, quinoclamine, by transcriptomic analysis.

Authors:  W-Y Cheng; J-C Lien; C-Y Hsiang; S-L Wu; C-C Li; H-Y Lo; J-C Chen; S-Y Chiang; J-A Liang; T-Y Ho
Journal:  Br J Pharmacol       Date:  2009-04-30       Impact factor: 8.739

5.  2-Chloro-3-(4-chloro-benzamido)-1,4-naphthoquinone.

Authors:  Yakini Brandy; Ray J Butcher; Tolulope A Adesiyun; Solomon Berhe; Oladapo Bakare
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-12-10

6.  Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes.

Authors:  Yiwen Yang; Chunxiang Kuang; Hui Jin; Qing Yang; Zhongkui Zhang
Journal:  Beilstein J Org Chem       Date:  2011-12-12       Impact factor: 2.883

7.  2,3-Dichloro-5,8-dimeth-oxy-1,4-naphtho-quinone.

Authors:  Maraizu Ukaegbu; Ray J Butcher; N M Enwerem; Oladapo Bakare; Charles Hosten
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-06-13

8.  A highly green approach towards aromatic nitro group substitutions: catalyst free reactions of nitroimidazoles with carbon nucleophiles in water.

Authors:  Syed Raza Shah; Muhammad Ali; Muhammad U Anwar; Ahmed Al-Harrasi
Journal:  RSC Adv       Date:  2020-06-08       Impact factor: 3.361

9.  N-(1,4-Dioxo-1,4-dihydro-naphthalen-2-yl)benzamide.

Authors:  Yakini Brandy; Ray J Butcher; Oladapo Bakare
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-08-25

10.  Modulation of basophils' degranulation and allergy-related enzymes by monomeric and dimeric naphthoquinones.

Authors:  Brígida R Pinho; Carla Sousa; Patrícia Valentão; Jorge M A Oliveira; Paula B Andrade
Journal:  PLoS One       Date:  2014-02-28       Impact factor: 3.240
  10 in total

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