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Literature DB >> 7785970

Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation.

E R Dabbs¹, K Yazawa, Y Mikami, M Miyaji, N Morisaki, S Iwasaki, K Furihata.

Abstract

Several fast-growing Mycobacterium strains were found to inactivate rifampin. Two inactivated compounds (RIP-Ma and RIP-Mb) produced by these organisms were different from previously reported derivatives, i.e., phosphorylated or glucosylated derivatives, of the antibiotic. The structures of RIP-Ma and RIP-Mb were determined to be those of 3-formyl-23-[O-(alpha-D-ribofuranosyl)]rifamycin SV and 23-[O-(alpha-D-ribofuranosyl)]rifampin, respectively. To our knowledge, this is the first known example of ribosylation as a mechanism of antibiotic inactivation.

Entities: Chemical Gene

Mesh：

Substances：
Rifampin

Year: 1995 PMID： 7785970 PMCID： PMC162673 DOI： 10.1128/AAC.39.4.1007

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

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Journal: J Bacteriol Date: 1992-01 Impact factor: 3.490

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Journal: Antimicrob Agents Chemother Date: 1989-12 Impact factor: 5.191

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Journal: Diagn Microbiol Infect Dis Date: 1994-04 Impact factor: 2.803

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Authors: E Cundliffe
Journal: Antimicrob Agents Chemother Date: 1992-02 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 1994-10 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 1994-09 Impact factor: 5.191

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Journal: J Antibiot (Tokyo) Date: 1993-10 Impact factor: 2.649

26 in total

1. Plasmid-mediated rifampin resistance encoded by an arr-2-like gene cassette in Klebsiella pneumoniae producing an ACC-1 class C beta-lactamase.

Authors: G Arlet; D Nadjar; J L Herrmann; J L Donay; P H Lagrange; A Philippon
Journal: Antimicrob Agents Chemother Date: 2001-10 Impact factor: 5.191

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Authors: A Telenti
Journal: Thorax Date: 1998-09 Impact factor: 9.139

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Authors: G E Louw; R M Warren; N C Gey van Pittius; C R E McEvoy; P D Van Helden; T C Victor
Journal: Antimicrob Agents Chemother Date: 2009-05-18 Impact factor: 5.191

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Authors: S Quan; T Imai; Y Mikami; K Yazawa; E R Dabbs; N Morisaki; S Iwasaki; Y Hashimoto; K Furihata
Journal: Antimicrob Agents Chemother Date: 1999-01 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 2000-10 Impact factor: 5.191

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Journal: Antimicrob Agents Chemother Date: 1997-01 Impact factor: 5.191

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Authors: David C Alexander; Joses R W Jones; Jun Liu
Journal: Antimicrob Agents Chemother Date: 2003-10 Impact factor: 5.191