Literature DB >> 8980786

Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic.

S J Andersen1, S Quan, B Gowan, E R Dabbs.   

Abstract

A DNA clone from Rhodococcus equi conferring low-level rifampin resistance through the ability to inactivate this antibiotic via its decomposition was identified. The iri (inactivation of rifampin) gene consisted of an open reading frame of 1,437 bp encoding a 479-amino-acid sequence strongly resembling those of monooxygenases acting upon phenolic compounds or involved in polyketide antibiotic synthesis. When expressed in Escherichia coli, the gene conferred resistance to a > 50-micrograms/ml concentration of the drug.

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Year:  1997        PMID： 8980786      PMCID： PMC163691     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Different rifampicin inactivation mechanisms in Nocardia and related taxa.

Authors:  Y Tanaka; K Yazawa; E R Dabbs; K Nishikawa; H Komaki; Y Mikami; M Miyaji; N Morisaki; S Iwasaki
Journal:  Microbiol Immunol       Date:  1996       Impact factor: 1.955

2.  Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline.

Authors:  T Dairi; T Nakano; K Aisaka; R Katsumata; M Hasegawa
Journal:  Biosci Biotechnol Biochem       Date:  1995-06       Impact factor: 2.043

3.  Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation.

Authors:  E R Dabbs; K Yazawa; Y Mikami; M Miyaji; N Morisaki; S Iwasaki; K Furihata
Journal:  Antimicrob Agents Chemother       Date:  1995-04       Impact factor: 5.191

4.  Inactivation of rifampin by Nocardia brasiliensis.

Authors:  K Yazawa; Y Mikami; A Maeda; M Akao; N Morisaki; S Iwasaki
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

5.  Rifampicin: a new orally active rifamycin.

Authors:  N Maggi; C R Pasqualucci; R Ballotta; P Sensi
Journal:  Chemotherapy       Date:  1966       Impact factor: 2.544

6.  Rifampicin inactivation by Bacillus species.

Authors:  E R Dabbs; K Yazawa; Y Tanaka; Y Mikami; M Miyaji; S J Andersen; N Morisaki; S Iwasaki; O Shida; H Takagi
Journal:  J Antibiot (Tokyo)       Date:  1995-08       Impact factor: 2.649

7.  Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae.

Authors:  Keqian Yang; Lei Han; Stephen W Ayer; Leo C Vining
Journal:  Microbiology (Reading)       Date:  1996-01       Impact factor: 2.777

Review 8.  Infections caused by nondiphtheria corynebacteria.

Authors:  B A Lipsky; A C Goldberger; L S Tompkins; J J Plorde
Journal:  Rev Infect Dis       Date:  1982 Nov-Dec

9.  Phosphorylative inactivation of rifampicin by Nocardia otitidiscaviarum.

Authors:  K Yazawa; Y Mikami; A Maeda; N Morisaki; S Iwasaki
Journal:  J Antimicrob Chemother       Date:  1994-06       Impact factor: 5.790

10.  Triple hydroxylation of tetracenomycin A2 to tetracenomycin C in Streptomyces glaucescens. Overexpression of the tcmG gene in Streptomyces lividans and characterization of the tetracenomycin A2 oxygenase.

Authors:  B Shen; C R Hutchinson
Journal:  J Biol Chem       Date:  1994-12-02       Impact factor: 5.157
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  22 in total

Review 1.  Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.

Authors:  Barbara A Brown-Elliott; Kevin A Nash; Richard J Wallace
Journal:  Clin Microbiol Rev       Date:  2012-07       Impact factor: 26.132

2.  Virulence plasmid of Rhodococcus equi contains inducible gene family encoding secreted proteins.

Authors:  B A Byrne; J F Prescott; G H Palmer; S Takai; V M Nicholson; D C Alperin; S A Hines
Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

3.  Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes.

Authors:  Peter Spanogiannopoulos; Maulik Thaker; Kalinka Koteva; Nicholas Waglechner; Gerard D Wright
Journal:  Antimicrob Agents Chemother       Date:  2012-07-16       Impact factor: 5.191

4.  A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.

Authors:  Peter Spanogiannopoulos; Nicholas Waglechner; Kalinka Koteva; Gerard D Wright
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-28       Impact factor: 11.205

5.  Ribosylative inactivation of rifampin by Mycobacterium smegmatis is a principal contributor to its low susceptibility to this antibiotic.

Authors:  S Quan; H Venter; E R Dabbs
Journal:  Antimicrob Agents Chemother       Date:  1997-11       Impact factor: 5.191

6.  Identification and mutagenesis by allelic exchange of choE, encoding a cholesterol oxidase from the intracellular pathogen Rhodococcus equi.

Authors:  J Navas; B González-Zorn; N Ladrón; P Garrido; J A Vázquez-Boland
Journal:  J Bacteriol       Date:  2001-08       Impact factor: 3.490

7.  Contribution of rpoB2 RNA polymerase beta subunit gene to rifampin resistance in Nocardia species.

Authors:  Jun Ishikawa; Kazuhiro Chiba; Haruyo Kurita; Hiroyuki Satoh
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

8.  The cell wall of the pathogenic bacterium Rhodococcus equi contains two channel-forming proteins with different properties.

Authors:  Franziska G Riess; Marion Elflein; Michael Benk; Bettina Schiffler; Roland Benz; Natalie Garton; Iain Sutcliffe
Journal:  J Bacteriol       Date:  2003-05       Impact factor: 3.490

9.  Identification of a novel conserved sequence motif in flavoprotein hydroxylases with a putative dual function in FAD/NAD(P)H binding.

Authors:  M H Eppink; H A Schreuder; W J Van Berkel
Journal:  Protein Sci       Date:  1997-11       Impact factor: 6.725

10.  Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr.

Authors:  Jennifer Baysarowich; Kalinka Koteva; Donald W Hughes; Linda Ejim; Emma Griffiths; Kun Zhang; Murray Junop; Gerard D Wright
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-18       Impact factor: 11.205
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