Literature DB >> 8244890

Inactivated products of rifampicin by pathogenic Nocardia spp.: structures of glycosylated and phosphorylated metabolites of rifampicin and 3-formylrifamycin SV.

N Morisaki1, S Iwasaki, K Yazawa, Y Mikami, A Maeda.   

Abstract

Rifampicin (1) was converted into four inactivated products by pathogenic Nocardia, RIP-1 and RIP-2 by N. brasiliensis and RIP-3 and RIP-4 by N. otitidiscaviarum. MS and NMR analysis showed the compounds to be 3-formyl-23-[O-(beta-D-glucopyranosyl)]rifamycin SV (2), 23-[O-(beta-D-glucopyranosyl)]rifampicin (3), 21-(O-phosphoryl)rifampicin (4) and 3-formyl-21-(O-phosphoryl)-rifamycin SV (5), respectively.

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Year:  1993        PMID： 8244890     DOI： 10.7164/antibiotics.46.1605

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  ADP-ribosylation as an intermediate step in inactivation of rifampin by a mycobacterial gene.

Authors:  S Quan; T Imai; Y Mikami; K Yazawa; E R Dabbs; N Morisaki; S Iwasaki; Y Hashimoto; K Furihata
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

2.  Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation.

Authors:  E R Dabbs; K Yazawa; Y Mikami; M Miyaji; N Morisaki; S Iwasaki; K Furihata
Journal:  Antimicrob Agents Chemother       Date:  1995-04       Impact factor: 5.191

3.  Inactivation of the macrolide antibiotics erythromycin, midecamycin, and rokitamycin by pathogenic Nocardia species.

Authors:  K Yazawa; Y Mikami; T Sakamoto; Y Ueno; N Morisaki; S Iwasaki; K Furihata
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

4.  Mechanism of Rifampicin Inactivation in Nocardia farcinica.

Authors:  Heba Abdelwahab; Julia S Martin Del Campo; Yumin Dai; Camelia Adly; Sohby El-Sohaimy; Pablo Sobrado
Journal:  PLoS One       Date:  2016-10-05       Impact factor: 3.240

5.  Discovery of a New Natural Product and a Deactivation of a Quorum Sensing System by Culturing a "Producer" Bacterium With a Heat-Killed "Inducer" Culture.

Authors:  Libang Liang; Amanda Sproule; Brad Haltli; Douglas H Marchbank; Fabrice Berrué; David P Overy; Kate McQuillan; Martin Lanteigne; Noelle Duncan; Hebelin Correa; Russell G Kerr
Journal:  Front Microbiol       Date:  2019-01-17       Impact factor: 5.640
  5 in total

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