Literature DB >> 3653885

The fragile site (17)(p12): induction by AT-specific DNA-ligands and population cytogenetics.

M Schmid1, W Feichtinger, C Deubelbeiss, E Weller.   

Abstract

The rare fragile site at 17p12 can be induced in lymphocyte cultures with the AT-specific DNA-ligands distamycin A, DAPI, Hoescht 33258 and berenil. The optimum culture conditions for the experimental induction of fra(17)(p12) were studied. There are indications that fra(17)(p12) is a late-replicating chromosome region in which AT-rich DNA is located. The fragile site also occurs spontaneously in cell cultures of most fra(17)(p12) carriers. A population screening of 250 unselected individuals showed that the frequency of carriers heterozygous for fra(17)(p12) is 2%. The results are compatible with a population being in Hardy-Weinberg equilibrium with respect to fra(17)(p12) and its non-fragile allelomorph. Neither the heterozygous nor the homozygous condition of fra(17)(p12) have any deleterious effects.

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Year:  1987        PMID： 3653885     DOI： 10.1007/BF00272376

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  13 in total

1.  The sites and relative frequencies of secondary constrictions in human somatic chromosomes.

Authors:  M A FERGUSON-SMITH; M E FERGUSON-SMITH; P M ELLIS; M DICKSON
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2.  Inheritance of marker chromosomes from a cytogenetic survey of congenital heart disease.

Authors:  E C Moores; J M Anders; R Emanuel
Journal:  Ann Hum Genet       Date:  1966-07       Impact factor: 1.670

3.  A homozygous chromosomal variant.

Authors:  J M Berg; J A Faunch; M J Pendrey; L S Penrose; M A Ridler; A Shapiro
Journal:  Lancet       Date:  1969-03-08       Impact factor: 79.321

4.  Satellites on the long Y chromosome arm: a familial Y-autosome translocation in man.

Authors:  W Schmid
Journal:  Cytogenetics       Date:  1969

5.  Structural polymorphism in chromosome 17.

Authors:  E Schmid; M Bauchinger
Journal:  Nature       Date:  1969-01-25       Impact factor: 49.962

Review 6.  The cri-du-chat syndrome with an apparently normal karyotype.

Authors:  D D McGavin; J S Cant; M A Ferguson-Smith; P M Ellis
Journal:  Lancet       Date:  1967-08-12       Impact factor: 79.321

7.  Heritable fragile sites on human chromosomes. XI. Factors affecting expression of fragile sites at 10q25, 16q22, and 17p12.

Authors:  G R Sutherland; P B Jacky; E G Baker
Journal:  Am J Hum Genet       Date:  1984-01       Impact factor: 11.025

8.  Homozygosity for fragile site at 17p12 in a 28-year-old healthy man.

Authors:  V Izakovic
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

9.  Silver staining studies on the short arm variant of human chromosome 17.

Authors:  N Oliver; U Francke; K M Taylor
Journal:  Hum Genet       Date:  1978-05-16       Impact factor: 4.132

10.  Heritable fragile sites on human chromosomes. IX. Population cytogenetics and segregation analysis of the BrdU-requiring fragile site at 10q25.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1982-09       Impact factor: 11.025
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  2 in total

1.  Population cytogenetics of folate-sensitive fragile sites. II. Autosomal rare fragile sites.

Authors:  M Kähkönen; C Tengström; T Alitalo; R Matilainen; M Kaski; E Airaksinen
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

2.  Molecular mechanism of upregulation of survivin transcription by the AT-rich DNA-binding ligand, Hoechst33342: evidence for survivin involvement in drug resistance.

Authors:  Jianguo Wu; Pasha Apontes; Lei Song; Ping Liang; Lily Yang; Fengzhi Li
Journal:  Nucleic Acids Res       Date:  2007-03-28       Impact factor: 16.971
  2 in total

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