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Literature DB >> 3972412

Fragile sites and structural rearrangements in cancer.

Abstract

We retracted information from a computerized databank which contains the cytogenetic findings of 17,000 patients with leukemia and lymphoma. Cytogenetic data from patients with solid tumors were compiled from Dr. Mitelman's catalogue on "Chromosome aberrations in cancer". We compared the observed distribution of breaks in chromosome bands involved in structural rearrangements with the random distribution of breaks generated by Monte Carlo simulation and showed that a majority but not all of the bands known to contain a fragile site are involved in structural aberrations in cancer and that some of them are associated with specific chromosome structural changes in specific types of cancer.

Entities: Disease Species

Mesh：

Year: 1985 PMID： 3972412 DOI： 10.1007/bf00293279

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

34 in total

1. Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.

Authors: J D Rowley
Journal: Ann Genet Date: 1973-06

2. Heritable fragile sites in cancer.

Authors: M M LeBeau; J D Rowley
Journal: Nature Date: 1984 Apr 12-18 Impact factor: 49.962

3. A new familial "fragile site" on chromosome 16 (q23-24). Cytogenetic and clinical considerations.

Authors: F Shabtai; D Klar; R Nissimov; D Vardimon; J Hart; I Halbrecht
Journal: Hum Genet Date: 1983 Impact factor: 4.132

4. Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells.

Authors: S Pathak; L C Strong; R E Ferrell; A Trindade
Journal: Science Date: 1982-09-03 Impact factor: 47.728

5. Cytogenetic abnormalities in a patient with hypercalcemia and papillary thyroid carcinoma.

Authors: S Pathak; T C Hsu; N Samaan; R C Hickey
Journal: Hum Genet Date: 1982 Impact factor: 4.132

6. Heritable fragile sites and lymphocyte culture medium containing BrdU.

Authors: J M Scheres; T W Hustinx
Journal: Am J Hum Genet Date: 1980-07 Impact factor: 11.025

7. Karyotype peculiarities of malignant lymphomas.

Authors: E W Fleischman; E L Prigogina
Journal: Hum Genet Date: 1977-03-14 Impact factor: 4.132

8. Coincidence between fragile site expression and interstitial deletion of chromosome 11 in a case of myelofibrosis.

Authors: M Sessarego; F Ajmar; R Ravazzolo; G L Bianchi Scarrà; C Garrè; P Boccaccio
Journal: Hum Genet Date: 1983 Impact factor: 4.132

9. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

Authors:
Journal: Cytogenet Cell Genet Date: 1981

10. Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association.

Authors: D C Arthur; C D Bloomfield
Journal: Blood Date: 1983-05 Impact factor: 22.113

20 in total

10. Cancer in relatives of leukemic patients with chromosomal rearrangements at rare (heritable) fragile-site locations in their malignant cells.

Authors: E H Mules; J R Testa; G H Thomas; H Abbey; B H Cohen
Journal: Am J Hum Genet Date: 1989-06 Impact factor: 11.025

Fragile sites and structural rearrangements in cancer.

1. Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.

2. Heritable fragile sites in cancer.

3. A new familial "fragile site" on chromosome 16 (q23-24). Cytogenetic and clinical considerations.

4. Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells.

5. Cytogenetic abnormalities in a patient with hypercalcemia and papillary thyroid carcinoma.

6. Heritable fragile sites and lymphocyte culture medium containing BrdU.

7. Karyotype peculiarities of malignant lymphomas.

8. Coincidence between fragile site expression and interstitial deletion of chromosome 11 in a case of myelofibrosis.

9. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

10. Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association.

1. Non random distribution of lesions induced by deoxyribonuclease I in human chromosomes.

2. Genetic determination of fragile-site expression.

3. Fragile sites and statistics.

4. Population cytogenetics of rare fragile sites in Japan.

5. Different inducibility and possible significance of several concomitant "fragile sites" in two brothers.

6. Breakpoints in variant Philadelphia translocations in chronic myeloid leukemia.

7. The fragile site (16) (q22). I. Induction by AT-specific DNA-ligands and population frequency.

8. A heritable fragile 12q24.13 segregating in a family with the fragile X chromosome.

9. Alpha-interferon and fragility at 16q22. A study on 15 selected controls and 146 selected patients.

10. Cancer in relatives of leukemic patients with chromosomal rearrangements at rare (heritable) fragile-site locations in their malignant cells.