Literature DB >> 1916761

"Spontaneous" FRA16B is a hot spot for sister chromatid exchanges.

T Lukusa1, E Meulepas, J P Fryns, H Van den Berghe, J J Cassiman.   

Abstract

Six heterozygous carriers of a fragile site at 16q22 were available for the current study. We demonstrated that the observed fragile site was a "BrdUrd-sensitive" fra(16)(q22) or FRA16B, capable of spontaneous expression in some individuals (= "spontaneous" FRA16B). Significant differences either in spontaneous or in ethylmethane sulfonate (EMS)-induced sister chromatid exchange (SCE) frequencies were found between the fragile 16q22 site, whether expressed or not, and its homologous normal site. These data complement our previous findings on FRAXA and provide additional arguments indicating that fragility and SCE are variable cytogenetic expressions of the same DNA structural alteration.

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Mesh：

Year:  1991        PMID： 1916761     DOI： 10.1007/bf00209017

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  16 in total

1.  Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1979-03       Impact factor: 11.025

2.  SCE variability in lymphocytes and fibroblasts. A controlled study.

Authors:  T Lukusa; P Vercauteren; H Van den Berghe; J J Cassiman
Journal:  Hum Genet       Date:  1988-10       Impact factor: 4.132

3.  The fragile site (16)(q22). II. Sister chromatid exchanges.

Authors:  M Schmid; W Feichtinger; T Haaf
Journal:  Hum Genet       Date:  1987-08       Impact factor: 4.132

4.  BrdU-sensitive fragile site on long arm of chromosome 16.

Authors:  G Croci
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

5.  DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes.

Authors:  T W Glover; C Berger; J Coyle; B Echo
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

6.  Induction of sister chromatid exchanges at common fragile sites.

Authors:  T W Glover; C K Stein
Journal:  Am J Hum Genet       Date:  1987-11       Impact factor: 11.025

7.  Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites.

Authors:  G R Sutherland
Journal:  Am J Hum Genet       Date:  1982-05       Impact factor: 11.025

8.  The use of distamycin A in human lymphocyte cultures.

Authors:  M Schmid; D A Hungerford; A Poppen; W Engel
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

9.  Heritable fragile sites on human chromosomes. XI. Factors affecting expression of fragile sites at 10q25, 16q22, and 17p12.

Authors:  G R Sutherland; P B Jacky; E G Baker
Journal:  Am J Hum Genet       Date:  1984-01       Impact factor: 11.025

10.  FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.

Authors:  T W Glover
Journal:  Am J Hum Genet       Date:  1981-03       Impact factor: 11.025
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