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Literature DB >> 7117032

Evidence that sister chromatid exchanges and chromatid breaks are two independent events.

Abstract

The relative frequencies of sister chromatid exchanges (SCE) and chromatid breaks in BrdU (5-bromodeoxyuridine) - sensitive site (lq22 leads to lq23) in Chinese hamster cells after BrdU incorporation were studied. The results show that chromatid breaks do not follow the "exchange hypothesis" and provide evidence that chromatid breaks and SCEs are two independent events despite some common features.

Entities: Chemical Species

Mesh：

Substances：
Bromodeoxyuridine

Year: 1982 PMID： 7117032 DOI： 10.1007/bf00330364

Source DB: PubMed Journal: Chromosoma ISSN： 0009-5915 Impact factor: 4.316

20 in total

1. Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia.

Authors: S A Latt; G Stetten; L A Juergens; G R Buchanan; P S Gerald
Journal: Proc Natl Acad Sci U S A Date: 1975-10 Impact factor: 11.205

2. Replication of human chromosomes in human-mouse hybrids: evidence that the timing of DNA synthesis is determined independently in each human chromosome.

Authors: M S Lin; R L Davidson
Journal: Somatic Cell Genet Date: 1975-01

Evidence that sister chromatid exchanges and chromatid breaks are two independent events.

1. Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia.

2. Replication of human chromosomes in human-mouse hybrids: evidence that the timing of DNA synthesis is determined independently in each human chromosome.

3. Parallel distribution of sister chromatid exchanges and chromosome aberrations.

4. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

5. On the formation of chromosomal aberrations.

6. The induction of chromatid deletions in accord with the breakage-and-reunion hypothesis.

7. The relation between chemically induced sister-chromatid exchanges and chromatid breakage.

8. Proposed banding nomenclature for the Chinese hamster chromosomes (Cricetulus griseus).

9. Sister chromatid exchange in human chromosomes from normal individuals and patients with ataxia telangiectasia.

10. Detection of sister chromatid exchanges by 4'-6-diamidino-2-phenylindole fluorescence.

1. Induction of distamycin A-inducible rare fragile sites and increased sister chromatid exchanges at the fragile site.