Literature DB >> 719230

Rat vas deferens: a specific bioassay for endogenous opioid peptides.

S Lemaire, J Magnan, D Regoli.   

Abstract

The electrically-evoked contractions of the rat vas deferens were selectively inhibited by beta-endorphin, the preparation being much less sensitive to enkephalins and narcotic analgesic drugs. However, introduction of D-Ala in position 2 of [Leu]-enkephalin enhanced the activity of the opioid peptide to the order of that of beta-endorphin. It is concluded that the rat vas deferens preparation constitutes a specific bioassay for endogenous opioid peptides and related compounds.

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Year:  1978        PMID： 719230      PMCID： PMC1668554          DOI： 10.1111/j.1476-5381.1978.tb08653.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.

Authors:  B M Cox; A Goldstein; C H Hi
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

2.  beta-Endorphin: structure-activity relationships in the guinea pig ileum and opiate receptor binding assays.

Authors:  B A Doneen; D Chung; D Yamashiro; P Y Law; H H Loh; C H Li
Journal:  Biochem Biophys Res Commun       Date:  1977-01-24       Impact factor: 3.575

3.  The synthesis and opiate activity of beta-endorphin.

Authors:  C H Li; S Lemaire; D Yamashiro; B A Doneen
Journal:  Biochem Biophys Res Commun       Date:  1976-07-12       Impact factor: 3.575

4.  The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

Authors:  W R Martin; C G Eades; J A Thompson; R E Huppler; P E Gilbert
Journal:  J Pharmacol Exp Ther       Date:  1976-06       Impact factor: 4.030

5.  A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens.

Authors:  G Henderson; J Hughes; H W Kosterlitz
Journal:  Br J Pharmacol       Date:  1972-12       Impact factor: 8.739

6.  [Endorphins, hypothalamic and neurohypophysial peptides with morphinomimetic activity: isolation and molecular structure of alpha-endorphin].

Authors:  R Guillemin; N Ling; R Burgus
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1976-02-23

7.  Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antogonist potencies of narcotic analgesics.

Authors:  J Hughes; H W Kosterlitz; F M Leslie
Journal:  Br J Pharmacol       Date:  1975-03       Impact factor: 8.739

8.  Identification of two related pentapeptides from the brain with potent opiate agonist activity.

Authors:  J Hughes; T W Smith; H W Kosterlitz; L A Fothergill; B A Morgan; H R Morris
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962

9.  (D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic.

Authors:  C B Pert; A Pert; J K Chang; B T Fong
Journal:  Science       Date:  1976-10-15       Impact factor: 47.728

10.  Endogenous opioid peptides: multiple agonists and receptors.

Authors:  J A Lord; A A Waterfield; J Hughes; H W Kosterlitz
Journal:  Nature       Date:  1977-06-09       Impact factor: 49.962
  10 in total
  18 in total

1.  The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties.

Authors:  J Magnan; S J Paterson; A Tavani; H W Kosterlitz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-06       Impact factor: 3.000

2.  Nociceptin, Phe(1)psi-nociceptin(1 - 13), nocistatin and prepronociceptin(154 - 181) effects on calcium channel currents and a potassium current in rat locus coeruleus in vitro.

Authors:  M Connor; C W Vaughan; E A Jennings; R G Allen; M J Christie
Journal:  Br J Pharmacol       Date:  1999-12       Impact factor: 8.739

3.  Unexpected antagonism in the rat vas deferens by benzomorphans which are agonists in other pharmacological tests.

Authors:  M G Gillan; H W Kosterlitz; J Magnan
Journal:  Br J Pharmacol       Date:  1981-01       Impact factor: 8.739

4.  Pharmacological differentiation of presynaptic inhibitory alpha-adrenoceptors and opiate receptors in the cat nictitating membrane.

Authors:  M L Dubocovich; S Z Langer
Journal:  Br J Pharmacol       Date:  1980-11       Impact factor: 8.739

5.  Enkephalin-like immunoreactivity in the human male genital tract.

Authors:  M Del Fiacco
Journal:  J Anat       Date:  1982-10       Impact factor: 2.610

6.  Investigation of action of enkephalin on the spontaneous and evoked release of acetylcholine from rat cortical and striatal slices.

Authors:  K Jhamandas; J Elliott
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

7.  Action of enkephalin analogues and morphine on brain acetylcholine release: differential reversal by naloxone and an opiate pentapeptide.

Authors:  K Jhamandas; M Sutak
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

8.  Species differences in the relative analgesic potencies of some classical opiates and opioid peptides.

Authors:  J I Székely; E Miglécz; S Bajusz
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

9.  Interactions between morphine and the opioid-like peptides in the rat vas deferens.

Authors:  F Huidobro; J P Huidobro-Toro; H Miranda
Journal:  Br J Pharmacol       Date:  1980-12       Impact factor: 8.739

10.  Inhibition of presynaptic alpha-2-adrenoceptor and opioid receptor agonist responses in the rat vas deferens by chronic imipramine treatment.

Authors:  R A Keith; A I Salama
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-04       Impact factor: 3.000
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