Literature DB >> 1207728

Identification of two related pentapeptides from the brain with potent opiate agonist activity.

J Hughes, T W Smith, H W Kosterlitz, L A Fothergill, B A Morgan, H R Morris.   

Abstract

Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.

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Year:  1975        PMID: 1207728     DOI: 10.1038/258577a0

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  432 in total

1.  Long time dynamics of Met-enkephalin: comparison of explicit and implicit solvent models.

Authors:  Min-yi Shen My; Karl F Freed
Journal:  Biophys J       Date:  2002-04       Impact factor: 4.033

Review 2.  Neurochemistry and behavior in man.

Authors:  G S Omenn
Journal:  West J Med       Date:  1976-12

3.  C-terminal fragment (residues 61-91) of beta-lipotropin: is it the natural opiate-like neurohormon of the brain?

Authors:  J I Székely; A Z Rónai; Z Dunai-Kovács; L Gráf; S Bajusz
Journal:  Experientia       Date:  1977-01-15

4.  Comparison of tolerance development and dependence capacities of morphine, beta-endorphin, and [D-Met2, Pro5]-enkephalinamide.

Authors:  E Miglécz; J I Székely; Z Dunai-Kovács
Journal:  Psychopharmacology (Berl)       Date:  1979-03-29       Impact factor: 4.530

5.  NCAD, a database integrating the intrinsic conformational preferences of non-coded amino acids.

Authors:  Guillem Revilla-López; Juan Torras; David Curcó; Jordi Casanovas; M Isabel Calaza; David Zanuy; Ana I Jiménez; Carlos Cativiela; Ruth Nussinov; Piotr Grodzinski; Carlos Alemán
Journal:  J Phys Chem B       Date:  2010-06-03       Impact factor: 2.991

6.  Effects of opiate antagonists on hormones and behavior of male and female rhesus monkeys.

Authors:  D H Abbott; S D Holman; M Berman; D A Neff; R W Goy
Journal:  Arch Sex Behav       Date:  1984-02

7.  Naloxone treatment attenuates food but not water intake in domestic pigeons.

Authors:  P Deviche; G Schepers
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

8.  Action of enkephalin analogues and morphine on brain acetylcholine release: differential reversal by naloxone and an opiate pentapeptide.

Authors:  K Jhamandas; M Sutak
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

9.  Effect of the administration of (d-Ala) 2methionine-enkephalin on the serotonin metabolism in rat brain.

Authors:  A Algeri; A Consolazione; G Calderini; G Achilli; E P Canas; S Garattini
Journal:  Experientia       Date:  1978-11-15

10.  Genotype dependent response of morphine and methionine-enkephalin on the electrically induced contractions of the mouse vas deferens.

Authors:  F Berti; F Bruno; C Omini; G Racagni
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-10       Impact factor: 3.000

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