| Literature DB >> 968485 |
C B Pert, A Pert, J K Chang, B T Fong.
Abstract
[D-Ala2]-Met-enkephalinamide (DALA), a synthetic enkephalin analog designed by in vitro analysis, binds to opiate receptors almost as tightly as methionine-enkephalin. Since it is not susceptible to degradation by brain enzymes, low doses (5 to 10 micrograms) cause profound, long-lasting, morphine-like analgesia when microinjected into rat brain.Entities:
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Year: 1976 PMID： 968485 DOI： 10.1126/science.968485
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728