Literature DB >> 1064855

Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.

B M Cox, A Goldstein, C H Hi.   

Abstract

The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.

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Year:  1976        PMID： 1064855      PMCID： PMC430398          DOI： 10.1073/pnas.73.6.1821

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  A synthetic peptide with morphine-like pharmacologic action.

Authors:  A Goldstein; J S Goldstein; B M Cox
Journal:  Life Sci       Date:  1975-12-01       Impact factor: 5.037

2.  A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties.

Authors:  B M Cox; K E Opheim; H Teschemacher; A Goldstein
Journal:  Life Sci       Date:  1975-06-15       Impact factor: 5.037

3.  Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.

Authors:  C H Li; D Chung
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

Review 4.  Peptide hormones.

Authors:  H S Tager; D F Steiner
Journal:  Annu Rev Biochem       Date:  1974       Impact factor: 23.643

5.  Isolation and amino-acid sequence of beta-LPH from sheep pituitary glands.

Authors:  C H Li; L Barnafi; M Chrétien; D Chung
Journal:  Nature       Date:  1965-12-11       Impact factor: 49.962

6.  Action of plasmin on ovine beta-lipotropin: revision of the carboxyl terminal sequence.

Authors:  L Gráf; C H Li
Journal:  Biochem Biophys Res Commun       Date:  1973-08-21       Impact factor: 3.575

7.  Inactivity of narcotic glucuronides as analgesics and on guinea-pig ileum.

Authors:  R Schulz; A Goldstein
Journal:  J Pharmacol Exp Ther       Date:  1972-11       Impact factor: 4.030

8.  [Endorphins, hypothalamic and neurohypophysial peptides with morphinomimetic activity: isolation and molecular structure of alpha-endorphin].

Authors:  R Guillemin; N Ling; R Burgus
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1976-02-23

9.  Identification of two related pentapeptides from the brain with potent opiate agonist activity.

Authors:  J Hughes; T W Smith; H W Kosterlitz; L A Fothergill; B A Morgan; H R Morris
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962

10.  Stereospecific binding of the potent narcotic analgesic (3H) Etorphine to rat-brain homogenate.

Authors:  E J Simon; J M Hiller; I Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1973-07       Impact factor: 11.205
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  36 in total

1.  Animal and molecular pharmacology of mixed agonist-antagonist analgesic drugs.

Authors:  M J Rance
Journal:  Br J Clin Pharmacol       Date:  1979       Impact factor: 4.335

2.  Tolerance and dependence evoked by an endogenous opiate peptide.

Authors:  A Lampert; M Nirenberg; W A Klee
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205

3.  beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.

Authors:  L H Lazarus; N Ling; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

4.  Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.

Authors:  N Ling; R Burgus; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

5.  Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.

Authors:  Kimitaka Shiotani; Tingyou Li; Anna Miyazaki; Yuko Tsuda; Sharon D Bryant; Akihiro Ambo; Yusuke Sasaki; Lawrence H Lazarus; Yoshio Okada
Journal:  Bioorg Med Chem Lett       Date:  2006-09-01       Impact factor: 2.823

6.  Binding of the endogenous nonpeptide morphine-like compound to opiate receptors.

Authors:  A J Blume; J Shorr; J P Finberg; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

7.  Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.

Authors:  Kimitaka Shiotani; Tingyou Li; Anna Miyazaki; Yuko Tsuda; Toshio Yokoi; Akihiro Ambo; Yusuke Sasaki; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Journal:  Bioorg Med Chem Lett       Date:  2007-08-28       Impact factor: 2.823

8.  beta-Endorphin-induced analgesia is inhibited by synthetic analogs of beta-endorphin.

Authors:  P Nicolas; R G Hammonds; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

Review 9.  Dynorphin--still an extraordinarily potent opioid peptide.

Authors:  Charles Chavkin
Journal:  Mol Pharmacol       Date:  2012-11-14       Impact factor: 4.436

10.  Action of morphine on the neuro-effector transmission in the guinea-pig ileum and in the mouse vas deferens.

Authors:  Y Ito; K Tajima
Journal:  J Physiol       Date:  1980-10       Impact factor: 5.182
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