Literature DB >> 6732505

Styrene metabolism in man: gas chromatographic separation of mandelic acid enantiomers in the urine of exposed persons.

M Korn, R Wodarz, W Schoknecht, H Weichardt, E Bayer.   

Abstract

D- and L-mandelic acid are separated by gas chromatography as isopropyl ester or isopropyl ester-isopropyl urethane on capillary columns, coated with Chirasil -Val. For its determination in urine the isopropyl ester procedure gives better results because other components of the urine do not cause interference. Thus D- and L-mandelic acid in the urine of exposed workers could be detected and verified by means of GC/MS. Occupational styrene exposure near the MAK-value (100 ppm) results in a L/D-enantiomer-ratio in urine of nearly 1.5.

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Year:  1984        PMID： 6732505     DOI： 10.1007/BF00316587

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  17 in total

1.  Catalytic activity and stereoselectivity of purified forms of rabbit liver microsomal cytochrome P-450 in the oxygenation of the (-) and (+) enantiomers of trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene.

Authors:  J Deutsch; K P Vatsis; M J Coon; J C Leutz; H V Gelboin
Journal:  Mol Pharmacol       Date:  1979-11       Impact factor: 4.436

2.  Enantiomer labelling, a method for the quantitative analysis of amino acids.

Authors:  H Frank; G J Nicholson; E Bayer
Journal:  J Chromatogr       Date:  1978-12-21

3.  A new gas chromatographic method for determination of mandelic acide in urine.

Authors:  K Engström; J Rantanen
Journal:  Int Arch Arbeitsmed       Date:  1974

4.  Human exposure to styrene. III. Elimination kinetics of urinary mandelic and phenylglyoxylic acids after single experimental exposure.

Authors:  M P Guillemin; D Bauer
Journal:  Int Arch Occup Environ Health       Date:  1979-11       Impact factor: 3.015

5.  [Styrene exposure. II. Percentage studies of absorption, excretion, and metabolism by human subjects].

Authors:  J R Caperos; B Humbert; P O Droz
Journal:  Int Arch Occup Environ Health       Date:  1979-01-15       Impact factor: 3.015

6.  Stereochemistry in the oxidative metabolism of styrene by hepatic microsomes.

Authors:  T Watabe; N Ozawa; K Yoshikawa
Journal:  Biochem Pharmacol       Date:  1981-06-15       Impact factor: 5.858

7.  Quantitative determination of styrene in biological samples and expired air by gas chromatography-mass spectrometry (selected ion monitoring).

Authors:  R J Karbowski; W H Braun
Journal:  J Chromatogr       Date:  1978-10-11

8.  Determination of urinary mandelic and phenylglyoxylic acids in styrene exposed workers and a control population.

Authors:  V J Elia; L A Anderson; T J Macdonald; A Carson; C R Buncher; S M Brooks
Journal:  Am Ind Hyg Assoc J       Date:  1980-12

9.  Styrene exposure in the fiberglass fabrication industry in Washington State.

Authors:  R L Schumacher; P A Breysse; W R Carlyon; R P Hibbard; G D Kleinman
Journal:  Am Ind Hyg Assoc J       Date:  1981-02

10.  Metabolism and toxicity of styrene.

Authors:  K C Leibman
Journal:  Environ Health Perspect       Date:  1975-06       Impact factor: 9.031
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  7 in total

1.  Styrene-7,8-oxide in blood of workers exposed to styrene.

Authors:  M Korn; W Gfrörer; J G Filser; W Kessler
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

2.  Stereometabolism of styrene in man. Urinary excretion of chiral styrene metabolites.

Authors:  M Korn; R Wodarz; K Drysch; F W Schmahl
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

Review 3.  Review: biocatalytic transformations of ferulic acid: an abundant aromatic natural product.

Authors:  J P Rosazza; Z Huang; L Dostal; T Volm; B Rousseau
Journal:  J Ind Microbiol       Date:  1995-12

4.  Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons.

Authors:  M Korn; R Wodarz; K Drysch; W Schoknecht; F W Schmahl
Journal:  Arch Toxicol       Date:  1985-12       Impact factor: 5.153

5.  Stereometabolism of ethylbenzene in man: gas chromatographic determination of urinary excreted mandelic acid enantiomers and phenylglyoxylic acid and their relation to the height of occupational exposure.

Authors:  M Korn; W Gfrörer; R Herz; I Wodarz; R Wodarz
Journal:  Int Arch Occup Environ Health       Date:  1992       Impact factor: 3.015

6.  Metabolism of styrene by Rhodococcus rhodochrous NCIMB 13259.

Authors:  A M Warhurst; K F Clarke; R A Hill; R A Holt; C A Fewson
Journal:  Appl Environ Microbiol       Date:  1994-04       Impact factor: 4.792

7.  A note on individual differences in the urinary excretion of optical enantiomers of styrene metabolites and of styrene-derived mercapturic acids in humans.

Authors:  E Hallier; H W Goergens; H Karels; K Golka
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153
  7 in total

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