Literature DB >> 2418806

Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons.

M Korn, R Wodarz, K Drysch, W Schoknecht, F W Schmahl.   

Abstract

A gas chromatographic procedure for the determination of phenylethyleneglycol enantiomers and phenylethanol isomers is described and applied to the investigation of urine samples from occupationally styrene-exposed workers (11 males, six females) and an unexposed control group. Phenylethyleneglycol enantiomers and 2-phenylethanol were present in the urine samples of exposed and unexposed individuals whereas 1-DL-phenylethanol was not found in control urine. The L/D enantiomer ratio of phenylethyleneglycol was found to be approximately 3 in the exposed group and 1.5 in the control group. Because of the close structural relation of these metabolites to the primarily formed epoxide, the results give further insight into the stereotoxicity of styrene in man.

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Year:  1985        PMID： 2418806     DOI： 10.1007/bf00348319

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  12 in total

1.  A specific gas chromatographic method for the determination of microsomal styrene monooxygenase and styrene epoxide hydratase activities.

Authors:  G Belvedere; J Pachecka; L Cantoni; E Mussini; M Salmona
Journal:  J Chromatogr       Date:  1976-04-07

Review 2.  Styrene, its experimental and clinical toxicology. A review.

Authors:  H Härkönen
Journal:  Scand J Work Environ Health       Date:  1978       Impact factor: 5.024

3.  Exposure to styrene. Uptake, distribution, metabolism and elimination in man.

Authors:  E Wigaeus; A Löf; R Bjurström; M B Nordqvist
Journal:  Scand J Work Environ Health       Date:  1983-12       Impact factor: 5.024

4.  [Styrene exposure. II. Percentage studies of absorption, excretion, and metabolism by human subjects].

Authors:  J R Caperos; B Humbert; P O Droz
Journal:  Int Arch Occup Environ Health       Date:  1979-01-15       Impact factor: 3.015

5.  Stereochemistry in the oxidative metabolism of styrene by hepatic microsomes.

Authors:  T Watabe; N Ozawa; K Yoshikawa
Journal:  Biochem Pharmacol       Date:  1981-06-15       Impact factor: 5.858

6.  Effect of alcohol on the kinetics of mandelic acid excretion in volunteers exposed to styrene vapour.

Authors:  H K Wilson; S M Robertson; H A Waldron; D Gompertz
Journal:  Br J Ind Med       Date:  1983-02

7.  Studies on metabolism and toxicity of styrene. V. The metabolism of styrene, racemic, (R)-(+)-, and (S)-(--)-phenyloxiranes in the rat.

Authors:  T Watabe; N Ozawa; K Yoshikawa
Journal:  J Pharmacobiodyn       Date:  1982-02

8.  Styrene metabolism in man: gas chromatographic separation of mandelic acid enantiomers in the urine of exposed persons.

Authors:  M Korn; R Wodarz; W Schoknecht; H Weichardt; E Bayer
Journal:  Arch Toxicol       Date:  1984-03       Impact factor: 5.153

9.  A very sensitive gas chromatographic method for the evaluation of styrene oxidase and styrene oxide hydratase activities.

Authors:  M van Bogaert; B Rollmann; G Noël; M Roberfroid; M Mercier
Journal:  Arch Toxicol Suppl       Date:  1978

10.  Mutagenicity of (R) and (S) styrene 7,8-oxide and the intermediary mercapturic acid metabolites formed from styrene 7,8-oxide.

Authors:  D A Pagano; B Yagen; O Hernandez; J R Bend; E Zeiger
Journal:  Environ Mutagen       Date:  1982
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  2 in total

1.  Stereometabolism of styrene in man. Urinary excretion of chiral styrene metabolites.

Authors:  M Korn; R Wodarz; K Drysch; F W Schmahl
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

2.  Effect of ethanol on the urinary excretion of mandelic and phenylglyoxylic acids after human exposure to styrene.

Authors:  S Cerný; J Mráz; J Flek; M Tichý
Journal:  Int Arch Occup Environ Health       Date:  1990       Impact factor: 3.015
  2 in total

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