Literature DB >> 3619649

Stereometabolism of styrene in man. Urinary excretion of chiral styrene metabolites.

M Korn, R Wodarz, K Drysch, F W Schmahl.   

Abstract

Chiral styrene metabolites obtained during initial styrene exposure of test persons were determined in urine samples using capillary gas chromatography. A typical time-dependent urinary concentration profile of one person over a 49-h period is presented and compared with the results of a previous study of occupationally exposed workers and an unexposed control group. Maximum levels of excretion of all styrene metabolites were observed at about the end of a 9-h workshift. Forty hours after exposure, the L/D-ratio of mandelic acid had subsided to the initial value, and the L/D-ratio of phenylethylene glycol to a value equal or slightly above the initial value.

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Year:  1987        PMID： 3619649     DOI： 10.1007/bf00296954

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  10 in total

1.  Human exposure to styrene. I. The gaschromatographic determination of urinary phenylglyoxylic acid using diazomethane derivatization.

Authors:  D Bauer; M Guillemin
Journal:  Int Arch Occup Environ Health       Date:  1976-04-28       Impact factor: 3.015

2.  A rapid colorimetric method for the determination of phenylglyoxylic and mandelic acids. Its application to the urinalysis of workers exposed to styrene vapour.

Authors: 
Journal:  Br J Ind Med       Date:  1970-04

3.  Hydroxylation of aromatic hydrocarbons in the rat.

Authors:  O M Bakke; R R Scheline
Journal:  Toxicol Appl Pharmacol       Date:  1970-05       Impact factor: 4.219

4.  Oxidation of styrene in liver microsomes.

Authors:  K C Leibman; E Ortiz
Journal:  Biochem Pharmacol       Date:  1969-02       Impact factor: 5.858

5.  Human exposure to styrene. III. Elimination kinetics of urinary mandelic and phenylglyoxylic acids after single experimental exposure.

Authors:  M P Guillemin; D Bauer
Journal:  Int Arch Occup Environ Health       Date:  1979-11       Impact factor: 3.015

6.  Exposure to styrene. Uptake, distribution, metabolism and elimination in man.

Authors:  E Wigaeus; A Löf; R Bjurström; M B Nordqvist
Journal:  Scand J Work Environ Health       Date:  1983-12       Impact factor: 5.024

7.  Stereochemistry in the oxidative metabolism of styrene by hepatic microsomes.

Authors:  T Watabe; N Ozawa; K Yoshikawa
Journal:  Biochem Pharmacol       Date:  1981-06-15       Impact factor: 5.858

8.  Effect of alcohol on the kinetics of mandelic acid excretion in volunteers exposed to styrene vapour.

Authors:  H K Wilson; S M Robertson; H A Waldron; D Gompertz
Journal:  Br J Ind Med       Date:  1983-02

9.  Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons.

Authors:  M Korn; R Wodarz; K Drysch; W Schoknecht; F W Schmahl
Journal:  Arch Toxicol       Date:  1985-12       Impact factor: 5.153

10.  Styrene metabolism in man: gas chromatographic separation of mandelic acid enantiomers in the urine of exposed persons.

Authors:  M Korn; R Wodarz; W Schoknecht; H Weichardt; E Bayer
Journal:  Arch Toxicol       Date:  1984-03       Impact factor: 5.153
  10 in total
  3 in total

1.  Styrene-7,8-oxide in blood of workers exposed to styrene.

Authors:  M Korn; W Gfrörer; J G Filser; W Kessler
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

2.  Long term neurotoxicity of styrene. A quantitative study of glial fibrillary acidic protein (GFA) and S-100.

Authors:  L E Rosengren; K G Haglid
Journal:  Br J Ind Med       Date:  1989-05

3.  A note on individual differences in the urinary excretion of optical enantiomers of styrene metabolites and of styrene-derived mercapturic acids in humans.

Authors:  E Hallier; H W Goergens; H Karels; K Golka
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153
  3 in total

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