Literature DB >> 809262

Metabolism and toxicity of styrene.

K C Leibman.   

Abstract

The absorption, blood levels, distribution, excretion, and biotransformation of styrene in man and experimental animals are briefly reviewed. The acute toxicity of styrene appears to be unrelated to its biotransformation. Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 809262      PMCID： PMC1475194          DOI： 10.1289/ehp.7511115

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  17 in total

1.  EXPERIMENTAL CARCINOGENICITY AND ACUTE TOXICITY OF REPRESENTATIVE EPOXIDES.

Authors:  C S WEIL; N CONDRA; C HAUN; J A STRIEGEL
Journal:  Am Ind Hyg Assoc J       Date:  1963 Jul-Aug

2.  Organic peroxides, hydrogen peroxide, epoxides, and neoplasia.

Authors:  P KOTIN; H L FALK
Journal:  Radiat Res       Date:  1963       Impact factor: 2.841

3.  The metabolism of styrene in the rat.

Authors:  I DANISHEFSKY; M WILLHITE
Journal:  J Biol Chem       Date:  1954-12       Impact factor: 5.157

4.  Enzymatic conjugation of epoxides with glutathione.

Authors:  T A Fjellstedt; R H Allen; B K Duncan; W B Jakoby
Journal:  J Biol Chem       Date:  1973-05-25       Impact factor: 5.157

5.  In vivo suppression of benzene and styrene oxidation by co-administered toluene in rats and effects of phenobarbital.

Authors:  M Ikeda; H Otsuji; T Imamura
Journal:  Xenobiotica       Date:  1972-03       Impact factor: 1.908

6.  Hydroxylation of aromatic hydrocarbons in the rat.

Authors:  O M Bakke; R R Scheline
Journal:  Toxicol Appl Pharmacol       Date:  1970-05       Impact factor: 4.219

7.  Biotransformation of ethyl benzene, styrene, and alpha-methylstyrene in man.

Authors:  Z Bardodej; E Bardodejova
Journal:  Am Ind Hyg Assoc J       Date:  1970 Mar-Apr

8.  The metabolism of phenethyl bromide, styrene and styrene oxide in the rabbit and rat.

Authors:  S P James; D A White
Journal:  Biochem J       Date:  1967-09       Impact factor: 3.857

9.  Toxicological studies of certain alkylated benzenes and benzene; experiments on laboratory animals.

Authors:  M A WOLF; V K ROWE; D D MCCOLLISTER; R L HOLLINGSWORTH; F OYEN
Journal:  AMA Arch Ind Health       Date:  1956-10

10.  Studies in detoxication. 73. The metabolism of alkylbenzenes: phenylacetylene and phenylethylene (styrene).

Authors:  A M EL MASRI; J N SMITH; R T WILLIAMS
Journal:  Biochem J       Date:  1958-02       Impact factor: 3.857
View more
  19 in total

1.  Human exposure to styrene. II. Quantitative and specific gaschromatographic analysis of urinary mandelic and phenylglyoxylic acids as an index of styrene exposure.

Authors:  M Guillemin; D Bauer
Journal:  Int Arch Occup Environ Health       Date:  1976-04-28       Impact factor: 3.015

2.  [Styrene exposure. An experimental study of pulmonary absorption and excretion (author's transl)].

Authors:  J G Fernández; J R Caperos
Journal:  Int Arch Occup Environ Health       Date:  1977-10-17       Impact factor: 3.015

3.  Structure-toxicity relationship study of para-halogenated styrene analogues in CYP2E1 transgenic cells.

Authors:  Jou-Ku Chung; Shuijie Shen; Zhiteng Jiang; Wei Yuan; Jiang Zheng
Journal:  Toxicol Lett       Date:  2012-02-16       Impact factor: 4.372

4.  No acute behavioural effects of exposure to styrene: a safe level of exposure?

Authors:  C Edling; K Ekberg
Journal:  Br J Ind Med       Date:  1985-05

5.  Human exposure to styrene. III. Elimination kinetics of urinary mandelic and phenylglyoxylic acids after single experimental exposure.

Authors:  M P Guillemin; D Bauer
Journal:  Int Arch Occup Environ Health       Date:  1979-11       Impact factor: 3.015

6.  The role of skin absorption as a route of exposure for volatile organic compounds (VOCs) in drinking water.

Authors:  H S Brown; D R Bishop; C A Rowan
Journal:  Am J Public Health       Date:  1984-05       Impact factor: 9.308

7.  Effect of styrene on dopamine receptors.

Authors:  A K Agrawal; S P Srivastava; P K Seth
Journal:  Bull Environ Contam Toxicol       Date:  1982-10       Impact factor: 2.151

8.  Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes.

Authors:  Shuijie Shen; Lei Li; Xinxin Ding; Jiang Zheng
Journal:  Chem Res Toxicol       Date:  2013-12-19       Impact factor: 3.739

9.  Increase in neuropsychiatric symptoms after occupational exposure to low levels of styrene.

Authors:  C Edling; H Anundi; G Johanson; K Nilsson
Journal:  Br J Ind Med       Date:  1993-09

10.  Styrene metabolism in man: gas chromatographic separation of mandelic acid enantiomers in the urine of exposed persons.

Authors:  M Korn; R Wodarz; W Schoknecht; H Weichardt; E Bayer
Journal:  Arch Toxicol       Date:  1984-03       Impact factor: 5.153
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.