Literature DB >> 7802595

Styrene-7,8-oxide in blood of workers exposed to styrene.

M Korn1, W Gfrörer, J G Filser, W Kessler.   

Abstract

A field study was carried out on 13 workers exposed to styrene vapors at time-weighted average concentrations between 10 and 73 ppm. The reactive intermediate styrene-7,8-oxide was determined in blood samples using a direct gas chromatographic method. Styrene-7,8-oxide concentrations were in the range between 0.9 and 4.1 micrograms/l blood. Linear correlations were found between styrene-7,8-oxide in blood and styrene in ambient air and blood. For an exposure concentration of 20 ppm styrene (German MAK value) a steady-state level of about 1 microgram styrene-7,8-oxide/l blood was calculated.

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Year:  1994        PMID： 7802595     DOI： 10.1007/s002040050107

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  25 in total

Review 1.  The genetic toxicology of styrene and styrene oxide.

Authors:  R Barale
Journal:  Mutat Res       Date:  1991-03       Impact factor: 2.433

2.  [Styrene exposure. An experimental study of pulmonary absorption and excretion (author's transl)].

Authors:  J G Fernández; J R Caperos
Journal:  Int Arch Occup Environ Health       Date:  1977-10-17       Impact factor: 3.015

3.  Human exposure to styrene. III. Elimination kinetics of urinary mandelic and phenylglyoxylic acids after single experimental exposure.

Authors:  M P Guillemin; D Bauer
Journal:  Int Arch Occup Environ Health       Date:  1979-11       Impact factor: 3.015

4.  Exposure to styrene. Uptake, distribution, metabolism and elimination in man.

Authors:  E Wigaeus; A Löf; R Bjurström; M B Nordqvist
Journal:  Scand J Work Environ Health       Date:  1983-12       Impact factor: 5.024

5.  Pharmacokinetics of inhaled styrene in human volunteers.

Authors:  J C Ramsey; J D Young; R J Karbowski; M B Chenoweth; L P McCarty; W H Braun
Journal:  Toxicol Appl Pharmacol       Date:  1980-03-30       Impact factor: 4.219

6.  Stereometabolism of styrene in man. Urinary excretion of chiral styrene metabolites.

Authors:  M Korn; R Wodarz; K Drysch; F W Schmahl
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

7.  In vitro kinetics of styrene and styrene oxide metabolism in rat, mouse, and human.

Authors:  A L Mendrala; P W Langvardt; K D Nitschke; J F Quast; R J Nolan
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

8.  Blood styrene concentrations in a "normal" population and in exposed workers 16 hours after the end of the workshift.

Authors:  F Brugnone; L Perbellini; G Z Wang; G Maranelli; E Raineri; E De Rosa; C Saletti; C Soave; L Romeo
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

9.  Rat and mouse forestomach tumors induced by chronic oral administration of styrene oxide.

Authors:  W Lijinsky
Journal:  J Natl Cancer Inst       Date:  1986-08       Impact factor: 13.506

10.  The formation of phenylethane-1,2-diol 2-acetate in the metabolism of styrene oxide by rabbit liver microsomes in vitro.

Authors:  C Battistini; G Bellucci; E Mastrorilli
Journal:  Xenobiotica       Date:  1979-01       Impact factor: 1.908
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  3 in total

1.  Predictors of occupational exposure to styrene and styrene-7,8-oxide in the reinforced plastics industry.

Authors:  B Serdar; R Tornero-Velez; D Echeverria; L A Nylander-French; L L Kupper; S M Rappaport
Journal:  Occup Environ Med       Date:  2006-06-06       Impact factor: 4.402

2.  A physiologic pharmacokinetic model for styrene and styrene-7,8-oxide in mouse, rat and man.

Authors:  G A Csanády; A L Mendrala; R J Nolan; J G Filser
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

Review 3.  Biomarker research in neurotoxicology: the role of mechanistic studies to bridge the gap between the laboratory and epidemiological investigations.

Authors:  L G Costa
Journal:  Environ Health Perspect       Date:  1996-03       Impact factor: 9.031
  3 in total

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