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Literature DB >> 6325896

Polyoma middle T antigen requires cooperation from another gene to express the malignant phenotype in vivo.

C Asselin, C Gélinas, P E Branton, M Bastin.

Abstract

The oncogenic potential of polyomavirus in newborn hamsters can be expressed by a recombinant encoding only the middle T protein. However, polyoma middle T requires the cooperation from small T to induce tumors in newborn rats. Similar complementary functions such as cocarcinogens or tumor promotors can be exerted by the simian virus 40 T antigens as well as by one or several products of the early region 1A of adenovirus 2.

Entities: Disease Species

Mesh：

Substances：
Antigens, Viral, Tumor

Year: 1984 PMID： 6325896 PMCID： PMC368794 DOI： 10.1128/mcb.4.4.755-760.1984

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

21 in total

1. Tumorigenic activity of cloned polyoma virus DNA in newborn rats.

Authors: C Gélinas; L Bouchard; M Bastin
Journal: Experientia Date: 1981-10-15

2. The roles of individual polyoma virus early proteins in oncogenic transformation.

Authors: M Rassoulzadegan; A Cowie; A Carr; N Glaichenhaus; R Kamen; F Cuzin
Journal: Nature Date: 1982-12-23 Impact factor: 49.962

3. Immortalization of rodent embryo fibroblasts by SV40 is maintained by the A gene.

Authors: C A Petit; M Gardes; J Feunteun
Journal: Virology Date: 1983-05 Impact factor: 3.616

4. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

Authors: H Land; L F Parada; R A Weinberg
Journal: Nature Date: 1983 Aug 18-24 Impact factor: 49.962

5. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.

Authors: H E Ruley
Journal: Nature Date: 1983 Aug 18-24 Impact factor: 49.962

6. Characterization of human adenovirus type 5 early region 1A polypeptides using antitumor sera and an antiserum specific for the carboxy terminus.

Authors: D T Rowe; S P Yee; J Otis; F L Graham; P E Branton
Journal: Virology Date: 1983-06 Impact factor: 3.616

7. Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells.

Authors: W W Colby; T Shenk
Journal: Proc Natl Acad Sci U S A Date: 1982-09 Impact factor: 11.205

8. Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini.

Authors: S P Yee; D T Rowe; M L Tremblay; M McDermott; P E Branton
Journal: J Virol Date: 1983-06 Impact factor: 5.103

8. Cooperation of middle and small T antigens of polyomavirus in transformation of established fibroblast and epithelial-like cell lines.

Authors: T Noda; M Satake; Y Yamaguchi; Y Ito
Journal: J Virol Date: 1987-07 Impact factor: 5.103

9. Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro.

Authors: W C Morgan; D R Kaplan; D C Pallas; T M Roberts
Journal: J Virol Date: 1988-09 Impact factor: 5.103

10. Mutation in the polyomavirus genome that activates the properties of large T associated with neoplastic transformation.

Authors: C Asselin; J Vass-Marengo; M Bastin
Journal: J Virol Date: 1986-01 Impact factor: 5.103

Polyoma middle T antigen requires cooperation from another gene to express the malignant phenotype in vivo.

1. Tumorigenic activity of cloned polyoma virus DNA in newborn rats.

2. The roles of individual polyoma virus early proteins in oncogenic transformation.

3. Immortalization of rodent embryo fibroblasts by SV40 is maintained by the A gene.

4. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

5. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.

6. Characterization of human adenovirus type 5 early region 1A polypeptides using antitumor sera and an antiserum specific for the carboxy terminus.

7. Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells.

8. Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini.

9. Tumor induction by direct injection of cloned v-src DNA into chickens.

10. Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein.

Review 1. Natural biology of polyomavirus middle T antigen.

2. Interactions between polyomavirus medium T antigen and three cellular proteins of 88, 61, and 37 kilodaltons.

3. Transcriptional regulation of early-response genes during polyomavirus infection.

Review 4. Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.

5. Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A.

6. The amino terminus of polyomavirus middle T antigen is required for transformation.

7. Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.

8. Cooperation of middle and small T antigens of polyomavirus in transformation of established fibroblast and epithelial-like cell lines.

9. Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro.

10. Mutation in the polyomavirus genome that activates the properties of large T associated with neoplastic transformation.