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Literature DB >> 19721090

Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.

Abstract

The small DNA tumor viruses have provided a very long-lived source of insights into many aspects of the life cycle of eukaryotic cells. In recent years, the emphasis has been on cancer-related signaling. Here we review murine polyomavirus middle T antigen, its mechanisms, and its downstream pathways of transformation. We concentrate on the MMTV-PyMT transgenic mouse, one of the most studied models of breast cancer, which permits the examination of in situ tumor progression from hyperplasia to metastasis.

Entities: Disease Species

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Year: 2009 PMID： 19721090 PMCID： PMC2738132 DOI： 10.1128/MMBR.00009-09

Source DB: PubMed Journal: Microbiol Mol Biol Rev ISSN： 1092-2172 Impact factor: 11.056

345 in total

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Authors: D DiMaio; D Mattoon
Journal: Oncogene Date: 2001-11-26 Impact factor: 9.867

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Journal: Bacteriol Rev Date: 1961-03

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Journal: Proc Natl Acad Sci U S A Date: 1990-04 Impact factor: 11.205

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Journal: J Virol Date: 1987-02 Impact factor: 5.103

5. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.

Authors: Ioanna G Maroulakou; William Oemler; Stephen P Naber; Philip N Tsichlis
Journal: Cancer Res Date: 2007-01-01 Impact factor: 12.701

6. Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation.

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Journal: Proc Natl Acad Sci U S A Date: 1982-06 Impact factor: 11.205

7. Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation.

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Journal: Cell Date: 1987-04-10 Impact factor: 41.582

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Authors: J E Thomas; A Aguzzi; P Soriano; E F Wagner; J S Brugge
Journal: Oncogene Date: 1993-09 Impact factor: 9.867

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Journal: Cell Date: 1984-10 Impact factor: 41.582

10. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression.

Authors: T Lifsted; T Le Voyer; M Williams; W Muller; A Klein-Szanto; K H Buetow; K W Hunter
Journal: Int J Cancer Date: 1998-08-12 Impact factor: 7.396

88 in total

1. The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner.

Authors: M Shanzer; I Ricardo-Lax; R Keshet; N Reuven; Y Shaul
Journal: Oncogene Date: 2014-11-03 Impact factor: 9.867

Review 2. Nuclear receptor coregulators: modulators of pathology and therapeutic targets.

Authors: David M Lonard; Bert W O'Malley
Journal: Nat Rev Endocrinol Date: 2012-06-26 Impact factor: 43.330

3. Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor.

Authors: Anne Masset; Catherine Maillard; Nor Eddine Sounni; Nathalie Jacobs; Françoise Bruyére; Philippe Delvenne; Marlene Tacke; Thomas Reinheckel; Jean-Michel Foidart; Lisa M Coussens; Agnès Noël
Journal: Int J Cancer Date: 2010-03-15 Impact factor: 7.396

Review 4. Expression of novel proteins by polyomaviruses and recent advances in the structural and functional features of agnoprotein of JC virus, BK virus, and simian virus 40.

Authors: A Sami Saribas; Pascale Coric; Serge Bouaziz; Mahmut Safak
Journal: J Cell Physiol Date: 2018-11-02 Impact factor: 6.384

Review 5. How to Choose a Mouse Model of Breast Cancer, a Genomic Perspective.

Authors: Matthew R Swiatnicki; Eran R Andrechek
Journal: J Mammary Gland Biol Neoplasia Date: 2019-06-21 Impact factor: 2.673

6. Nondestructive Detection of Targeted Microbubbles Using Dual-Mode Data and Deep Learning for Real-Time Ultrasound Molecular Imaging.

Authors: Dongwoon Hyun; Lotfi Abou-Elkacem; Rakesh Bam; Leandra L Brickson; Carl D Herickhoff; Jeremy J Dahl
Journal: IEEE Trans Med Imaging Date: 2020-04-09 Impact factor: 10.048