Literature DB >> 6308473

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.

H E Ruley.   

Abstract

The polyoma virus middle-T and the T24 Harvey ras1 genes are individually unable to transform primary baby rat kidney cells. Adenovirus early region 1A provides functions required by these genes to transform primary cells following DNA-mediated gene transfer. These results suggest that separate establishment and transforming functions are required for oncogenic transformation of primary cells in culture.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6308473     DOI： 10.1038/304602a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  419 in total

1.  Isolation of transformation suppressor genes by cDNA subtraction: lumican suppresses transformation induced by v-src and v-K-ras.

Authors:  N Yoshioka; H Inoue; K Nakanishi; K Oka; M Yutsudo; A Yamashita; A Hakura; H Nojima
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers.

Authors:  V Y Hua; W K Wang; P H Duesberg
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

3.  High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.

Authors:  A Sewing; B Wiseman; A C Lloyd; H Land
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

4.  Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals.

Authors:  R Sears; K Ohtani; J R Nevins
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

5.  Adenovirus infection of differentiated F9 cells results in a global shut-off of differentiation-induced gene expression.

Authors:  R J Weigel; J R Nevins
Journal:  Nucleic Acids Res       Date:  1990-10-25       Impact factor: 16.971

6.  Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression.

Authors:  B E Roberts; J S Miller; D Kimelman; C L Cepko; I R Lemischka; R C Mulligan
Journal:  J Virol       Date:  1985-11       Impact factor: 5.103

7.  Function of a human cyclin gene as an oncogene.

Authors:  P W Hinds; S F Dowdy; E N Eaton; A Arnold; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

Review 8.  Somatic cell fusion as a source of genetic rearrangement leading to metastatic variants.

Authors:  L Larizza; V Schirrmacher
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264

9.  Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation.

Authors:  Tsuyoshi Akagi; Ken Sasai; Hidesaburo Hanafusa
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-03       Impact factor: 11.205

10.  Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters.

Authors:  H K Wong; E B Ziff
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.