| Literature DB >> 6294529 |
M Rassoulzadegan, A Cowie, A Carr, N Glaichenhaus, R Kamen, F Cuzin.
Abstract
The expression in normal rat cells of modified polyoma virus genomes, separately encoding large T, middle T or small T antigens, has allowed the investigation of the roles of these proteins in oncogenic transformation. Middle T is sufficient to transform cells of established lines but the transformants are serum dependent. Large T lacks intrinsic oncogenic potential but can relieve the serum dependence of normal and transformed cells. Middle T alone cannot transform primary rat embryo fibroblasts.Entities:
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Year: 1982 PMID： 6294529 DOI： 10.1038/300713a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962