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Literature DB >> 6291029

Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells.

Abstract

Segments of the simian virus 40 (SV40) genome that encode only fragments of large tumor antigen can facilitate immortalization of secondary rat embryo cells. The phenotypes of the immortalized cells range from nearly "normal" to fully transformed. All of the cell lines contain SV40 sequences and express unstable NH2-terminal fragments of large tumor antigen. SV40 small tumor antigen does not appear to be essential for either immortalization or transformation.

Entities: Disease Species

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Year: 1982 PMID： 6291029 PMCID： PMC346860 DOI： 10.1073/pnas.79.17.5189

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

37 in total

1. Function of simian virus 40 gene A in transforming infection.

Authors: P Tegtmeyer
Journal: J Virol Date: 1975-03 Impact factor: 5.103

2. The stable classes of transformed cells induced by SV40 infection of established 3T3 cells and primary rat embryonic cells.

Authors: R Risser; D Rifkin; R Pollack
Journal: Cold Spring Harb Symp Quant Biol Date: 1975

3. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

4. Regulation of tumor antigen synthesis by simain virus 40 gene A.

Authors: P Tegtmeyer; M Schwartz; J K Collins; K Rundell
Journal: J Virol Date: 1975-07 Impact factor: 5.103

5. Autoregulation of simian virus 40 gene A by T antigen.

Authors: S I Reed; G R Stark; J C Alwine
Journal: Proc Natl Acad Sci U S A Date: 1976-09 Impact factor: 11.205

6. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors: P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal: J Mol Biol Date: 1977-06-15 Impact factor: 5.469

7. Isolation of high-molecular-weight DNA from mammalian cells.

Authors: M Gross-Bellard; P Oudet; P Chambon
Journal: Eur J Biochem Date: 1973-07-02

8. Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro.

Authors: S I Shin; V H Freedman; R Risser; R Pollack
Journal: Proc Natl Acad Sci U S A Date: 1975-11 Impact factor: 11.205

9. Construction and analysis of viable deletion mutants of simian virus 40.

Authors: T E Shenk; J Carbon; P Berg
Journal: J Virol Date: 1976-05 Impact factor: 5.103

10. Characterization of the autoregulation of simian virus 40 gene A.

Authors: J C Alwine; S I Reed; G R Stark
Journal: J Virol Date: 1977-10 Impact factor: 5.103

57 in total

1. Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization.

Authors: A Larose; N Dyson; M Sullivan; E Harlow; M Bastin
Journal: J Virol Date: 1991-05 Impact factor: 5.103

2. Immortalization of human fibroblasts transformed by origin-defective simian virus 40.

Authors: D S Neufeld; S Ripley; A Henderson; H L Ozer
Journal: Mol Cell Biol Date: 1987-08 Impact factor: 4.272

3. Immortalization of brain capillary endothelial cells with maintenance of structural characteristics of the blood-brain barrier endothelium.

Authors: O Durieu-Trautmann; N Foignant-Chaverot; J Perdomo; P Gounon; A D Strosberg; P O Couraud
Journal: In Vitro Cell Dev Biol Date: 1991-10

4. Simian virus 40 can overcome the antiproliferative effect of wild-type p53 in the absence of stable large T antigen-p53 binding.

Authors: D Michael-Michalovitz; F Yehiely; E Gottlieb; M Oren
Journal: J Virol Date: 1991-08 Impact factor: 5.103