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Literature DB >> 6171779

Antiviral activities of hybrids of two major human leukocyte interferons.

P K Weck, S Apperson, N Stebbing, P W Gray, D Leung, H M Shepard, D V Goeddel.

Abstract

Four hybrid human leukocyte interferon (LeIF or IFN-alpha) genes have been constructed by in vitro recombination of LeIF-A (IFN-alpha 2) and LeIF-D (IFN-alpha 1) genes at common restriction endonuclease sites located within their coding regions. These hybrid genes have been expressed in E. coli under trp promoter control. The interferons produced [LeIF-AD (BglII), -AD (PvuII), -DA (BglII), -DA (PvuII)] have antiviral properties distinct from the parental molecules LeIF-A and -D, varying considerably in their abilities to inhibit plaque formation by different viruses in a range of mammalian cells. All six of the cloned LeIFs exhibit the heat stability, pH 2 stability and antigenic specificity of natural leukocyte interferons.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1981 PMID： 6171779 PMCID： PMC327591 DOI： 10.1093/nar/9.22.6153

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

23 in total

1. Synthesis of human fibroblast interferon by E. coli.

Authors: D V Goeddel; H M Shepard; E Yelverton; D Leung; R Crea; A Sloma; S Pestka
Journal: Nucleic Acids Res Date: 1980-09-25 Impact factor: 16.971

2. The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.

Authors: S Nagata; N Mantei; C Weissmann
Journal: Nature Date: 1980-10-02 Impact factor: 49.962

3. The structure of eight distinct cloned human leukocyte interferon cDNAs.

Authors: D V Goeddel; D W Leung; T J Dull; M Gross; R M Lawn; R McCandliss; P H Seeburg; A Ullrich; E Yelverton; P W Gray
Journal: Nature Date: 1981-03-05 Impact factor: 49.962

4. Bacterial synthesis of a novel human leukocyte interferon.

Authors: E Yelverton; D Leung; P Weck; P W Gray; D V Goeddel
Journal: Nucleic Acids Res Date: 1981-02-11 Impact factor: 16.971

5. Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis virus replication in mouse cells.

Authors: C W Czarniecki; T Sreevalsan; R M Friedman; A Panet
Journal: J Virol Date: 1981-02 Impact factor: 5.103

6. Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors: A M Maxam; W Gilbert
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

7. Assignment of the disulphide bonds of leukocyte interferon.

Authors: R Wetzel
Journal: Nature Date: 1981-02-12 Impact factor: 49.962

8. At least three human type alpha interferons: structure of alpha 2.

Authors: M Streuli; S Nagata; C Weissmann
Journal: Science Date: 1980-09-19 Impact factor: 47.728

9. Human leukocyte interferon produced by E. coli is biologically active.

Authors: D V Goeddel; E Yelverton; A Ullrich; H L Heyneker; G Miozzari; W Holmes; P H Seeburg; T Dull; L May; N Stebbing; R Crea; S Maeda; R McCandliss; A Sloma; J M Tabor; M Gross; P C Familletti; S Pestka
Journal: Nature Date: 1980-10-02 Impact factor: 49.962

10. Mouse fibroblast (type I) and immune (type II) interferons: pronounced differences in affinity for gangliosides and in antiviral and antigrowth effects on mouse leukemia L-1210R cells.

Authors: H Ankel; C Krishnamurti; F Besançon; S Stefanos; E Falcoff
Journal: Proc Natl Acad Sci U S A Date: 1980-05 Impact factor: 11.205

22 in total

1. Generation of hybrid genes and proteins by vaccinia virus-mediated recombination: application to human immunodeficiency virus type 1 env.

Authors: L Gritz; A Destree; N Cormier; E Day; V Stallard; T Caiazzo; G Mazzara; D Panicali
Journal: J Virol Date: 1990-12 Impact factor: 5.103

Review 2. The cellular receptor of the alpha-beta interferons.

Authors: K E Mogensen; G Uzé; P Eid
Journal: Experientia Date: 1989-06-15

3. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

Authors: D J Capon; H M Shepard; D V Goeddel
Journal: Mol Cell Biol Date: 1985-04 Impact factor: 4.272

4. Simultaneous synthesis of human-, mouse- and chimeric epidermal growth factor genes via 'hybrid gene synthesis' approach.

Authors: W L Sung; D M Zahab; F L Yao; R Wu; S A Narang
Journal: Nucleic Acids Res Date: 1986-08-11 Impact factor: 16.971