Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.

Literature DB >> 6159536

The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.

Abstract

The 12 interferon (IFN)-related sequences detected in a human gene bank fall into not less than eight distinct classes, indicating that there are at least eight IFN-related genes. Most, if not all, of these direct the synthesis of an IFN in Escherichia coli. The sequence of one chromosomal gene and its flanking regions was identical to that deduced for the cDNA corresponding to IFN-alpha l mRNA. No evidence was found for the existence of an intron, in either the coding or the non-coding segments of the gene.

Entities: Gene Species

Mesh：

Substances：

Year: 1980 PMID： 6159536 DOI： 10.1038/287401a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

Keyword Cloud
Cited

108 in total

1. Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing.

Authors: Y Huang; K M Wimler; G G Carmichael
Journal: EMBO J Date: 1999-03-15 Impact factor: 11.598

2. Simian virus 40 late transcripts lacking excisable intervening sequences are defective in both stability in the nucleus and transport to the cytoplasm.

Authors: W S Ryu; J E Mertz
Journal: J Virol Date: 1989-10 Impact factor: 5.103

3. Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control.

Authors: R W Jackman; D L Beeler; L Fritze; G Soff; R D Rosenberg
Journal: Proc Natl Acad Sci U S A Date: 1987-09 Impact factor: 11.205

4. Splice site requirement for the efficient accumulation of polyoma virus late mRNAs.

Authors: N L Barrett; G G Carmichael; Y Luo
Journal: Nucleic Acids Res Date: 1991-06-11 Impact factor: 16.971

5. Changes of chromatin conformation around mouse interferon-beta gene associated with induction of interferon synthesis.

Authors: Y Higashi
Journal: Nucleic Acids Res Date: 1985-07-25 Impact factor: 16.971

10. Genomic footprinting: detection of putative regulatory proteins in the promoter region of the interferon alpha-1 gene in normal human tissues.

Authors: M Palmieri; M G Tovey
Journal: Mol Cell Biol Date: 1990-06 Impact factor: 4.272

The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.

1. Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing.

2. Simian virus 40 late transcripts lacking excisable intervening sequences are defective in both stability in the nucleus and transport to the cytoplasm.

3. Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control.

4. Splice site requirement for the efficient accumulation of polyoma virus late mRNAs.

5. Changes of chromatin conformation around mouse interferon-beta gene associated with induction of interferon synthesis.

6. A novel class of human type I interferons.

7. Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice.

8. Differential expression of human interferon genes.

9. Structure and expression in Escherichia coli of a cloned rat interferon-alpha gene.

10. Genomic footprinting: detection of putative regulatory proteins in the promoter region of the interferon alpha-1 gene in normal human tissues.