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Literature DB >> 6091048

A human IFN-beta 1 gene deleted of promoter sequences upstream from the TATA box is controlled post-transcriptionally by dsRNA.

Abstract

Induction of IFN-beta 1 RNA was studied in the mouse cell line SR117-21E transformed by a BPV episome containing the human IFN-beta 1 gene deleted of promoter sequences upstream from position -40. Nuclei isolated from these cells synthesize constitutively IFN-beta 1 RNA from the partially deleted promoter. The IFN-beta 1 RNA synthesized by nuclei of uninduced SR117-21E cells is similar to that made by nuclei of poly(rI):(rC)-induced cells, but does not accumulate and hence no IFN is produced unless the cells have been treated either by ds RNA or by cycloheximide. We conclude that the IFN-beta 1 gene has, in addition to the transcription control due to upstream promoter sequences, an additional post-transcriptional control acting on mRNA accumulation and linked to sequences close to the TATA box and RNA start site. Both controls are relieved by ds RNA.

Entities: Chemical Gene Species

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Year: 1984 PMID： 6091048 PMCID： PMC320137 DOI： 10.1093/nar/12.18.6979

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

35 in total

1. Production of high-titered interferon in cultures of human diploid cells.

Authors: E A Havell; J Vilcek
Journal: Antimicrob Agents Chemother Date: 1972-12 Impact factor: 5.191

2. Nucleotide sequence of the chromosomal gene for human fibroblast (beta 1) interferon and of the flanking regions.

Authors: W Degrave; R Derynck; J Tavernier; G Haegeman; W Fiers
Journal: Gene Date: 1981-08 Impact factor: 3.688

3. 5'-Terminal structure and mRNA stability.

Authors: Y Furuichi; A LaFiandra; A J Shatkin
Journal: Nature Date: 1977-03-17 Impact factor: 49.962

4. 'Single-stranded' DNA from phiX174 and M13 is cleaved by certain restriction endonucleases.

Authors: R W Blakesley; R D Wells
Journal: Nature Date: 1975-10-02 Impact factor: 49.962

5. Analysis of interferon mRNA in human fibroblast cells induced to produce interferon.

Authors: N B Raj; P M Pitha
Journal: Proc Natl Acad Sci U S A Date: 1981-12 Impact factor: 11.205

6. Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into cultured mouse cells.

Authors: S Ohno; T Taniguchi
Journal: Nucleic Acids Res Date: 1982-02-11 Impact factor: 16.971

Review 7. Variety in the level of gene control in eukaryotic cells.

Authors: J E Darnell
Journal: Nature Date: 1982-06-03 Impact factor: 49.962

8. Human fibroblast interferon gene lacks introns.

Authors: R M Lawn; J Adelman; A E Franke; C M Houck; M Gross; R Najarian; D V Goeddel
Journal: Nucleic Acids Res Date: 1981-03-11 Impact factor: 16.971

9. Efficient constitutive production of human fibroblast interferon by hamster cells transformed with the IFN-beta 1 gene fused to an SV40 early promoter.

Authors: Y Chernajovsky; Y Mory; L Chen; Z Marks; D Novick; M Rubinstein; M Revel
Journal: DNA Date: 1984-08

10. Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.

Authors: P Benech; Y Mory; M Revel; J Chebath
Journal: EMBO J Date: 1985-09 Impact factor: 11.598

10 in total

A human IFN-beta 1 gene deleted of promoter sequences upstream from the TATA box is controlled post-transcriptionally by dsRNA.

1. Production of high-titered interferon in cultures of human diploid cells.

2. Nucleotide sequence of the chromosomal gene for human fibroblast (beta 1) interferon and of the flanking regions.

3. 5'-Terminal structure and mRNA stability.

4. 'Single-stranded' DNA from phiX174 and M13 is cleaved by certain restriction endonucleases.

5. Analysis of interferon mRNA in human fibroblast cells induced to produce interferon.

6. Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into cultured mouse cells.

Review 7. Variety in the level of gene control in eukaryotic cells.

8. Human fibroblast interferon gene lacks introns.

9. Efficient constitutive production of human fibroblast interferon by hamster cells transformed with the IFN-beta 1 gene fused to an SV40 early promoter.

10. Identification of the translation products of human fibroblast interferon mRNA in reticulocyte lysates.

1. Transient expression of the beta interferon promoter in human cells.

2. Identification of an inducible factor that binds to a positive regulatory element of the human beta-interferon gene.

3. Posttranscriptional control of human gamma interferon gene expression in transfected mouse fibroblasts.

4. Overlapping positive and negative regulatory domains of the human beta-interferon gene.

5. Activation of the human beta-interferon gene requires an interferon-inducible factor.

6. Postinduction turnoff of beta-interferon gene expression.

7. Regulation of the mRNA for monocyte-derived neutrophil-activating peptide in differentiating HL60 promyelocytes.

8. Superinduction of the human interferon-beta promoter.

9. Two different virus-inducible elements are required for human beta-interferon gene regulation.

10. Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.