Literature DB >> 3034597

Superinduction of the human interferon-beta promoter.

H Dinter, H Hauser.   

Abstract

Superinduction, that is induction with simultaneous blocking of mRNA translation, enhances the induction of interferon-beta in response to virus or double-stranded RNA in human fibroblasts. Expression of the cloned IFN-beta gene upon transfer into heterologous cells reflects the endogeneous interferon expression with respect to induction or superinduction indicating the involvement of cellular mediators in this mode of gene regulation. Expression from gene hybrids in mouse Mo57/2 cells reveals that 5' flanking DNA sequences from the human IFN-beta gene are responsible for induction and superinduction. Superinduction of the human IFN-beta promoter is demonstrated in several rodent and primate cell lines. In addition, expression from promoter mutants in mouse cells indicates that DNA sequences responsible for induction and superinduction are identical.

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Year:  1987        PMID： 3034597      PMCID： PMC553439          DOI： 10.1002/j.1460-2075.1987.tb04796.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  36 in total

1.  Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.

Authors:  M Wigler; S Silverstein; L S Lee; A Pellicer; Y c Cheng; R Axel
Journal:  Cell       Date:  1977-05       Impact factor: 41.582

2.  Relationship between interferon production and interferon messenger RNA synthesis in human fibroblasts.

Authors:  N B Raj; P M Pitha
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

3.  Interferon messenger RNA content of human fibroblasts during induction, shutoff, and superinduction of interferon production.

Authors:  P B Sehgal; B Dobberstein; I Tamm
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

4.  Post-transcriptional control of interferon synthesis.

Authors:  J Vilcek; M H Ng
Journal:  J Virol       Date:  1971-05       Impact factor: 5.103

5.  Tyrosine transaminase induction in mammalian cells in tissue culture.

Authors:  G M Tomkins; E B Thompson; S Hayashi; T Gelehrter; D Granner; B Peterkofsky
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1966

6.  Enhancement of interferon production in mouse cell line, a high-yielding source of mouse interferon.

Authors:  V G Edy; A Billiau; P De Somer
Journal:  Appl Microbiol       Date:  1973-09

7.  Production of high-titered interferon in cultures of human diploid cells.

Authors:  E A Havell; J Vilcek
Journal:  Antimicrob Agents Chemother       Date:  1972-12       Impact factor: 5.191

8.  Regulation of cellular interferon production: enhancement by antimetabolites.

Authors:  Y H Tan; J A Armstrong; Y H Ke; M Ho
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205

9.  Stabilization of interferon messenger RNA activity by treatment of cells with metabolic inhibitors and lowering of the incubation temperature.

Authors:  J Vilcek; E A Havell
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

10.  Sequences involved in the regulated expression of the human interferon-beta1 gene in recombinant SV40 DNA vectors replicating in monkey cells.

Authors:  L Maroteaux; C Kahana; Y Mory; Y Groner; M Revel
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  11 in total

1.  Postinduction repression of the beta-interferon gene is mediated through two positive regulatory domains.

Authors:  L A Whittemore; T Maniatis
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

2.  Transcriptional and posttranscriptional control of c-fos gene expression in human monocytes.

Authors:  E Sariban; R Luebbers; D Kufe
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

Review 3.  Negative regulation of transcription in eukaryotes.

Authors:  A R Clark; K Docherty
Journal:  Biochem J       Date:  1993-12-15       Impact factor: 3.857

4.  Activation of human papillomavirus type 18 gene expression by herpes simplex virus type 1 viral transactivators and a phorbol ester.

Authors:  D Gius; L A Laimins
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

5.  Postinduction turnoff of beta-interferon gene expression.

Authors:  L A Whittemore; T Maniatis
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

6.  Innate immune responses in NF-kappaB-repressing factor-deficient mice.

Authors:  Natali Froese; Michael Schwarzer; Ina Niedick; Ursula Frischmann; Mario Köster; Andrea Kröger; Peter P Mueller; Mahtab Nourbakhsh; Bastian Pasche; Jörg Reimann; Peter Staeheli; Hansjörg Hauser
Journal:  Mol Cell Biol       Date:  2006-01       Impact factor: 4.272

7.  Human immunodeficiency virus type 1 Rev function requires continued synthesis of its target mRNA.

Authors:  S Iacampo; A Cochrane
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

8.  Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes.

Authors:  S Kirchhoff; F Schaper; H Hauser
Journal:  Nucleic Acids Res       Date:  1993-06-25       Impact factor: 16.971

9.  Priming of human monocytes for enhanced lipopolysaccharide responses: expression of alpha interferon, interferon regulatory factors, and tumor necrosis factor.

Authors:  M P Hayes; K C Zoon
Journal:  Infect Immun       Date:  1993-08       Impact factor: 3.441

10.  Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes.

Authors:  L F Reis; H Ruffner; G Stark; M Aguet; C Weissmann
Journal:  EMBO J       Date:  1994-10-17       Impact factor: 11.598
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