Literature DB >> 464569

Large-scale production and concentration of human lymphoid interferon.

F Klein, R T Ricketts, W I Jones, I A DeArmon, M J Temple, K C Zoon, P J Bridgen.   

Abstract

A stable and predictable production system is described for pilot plant quantities (milligram) of human lymphoid interferon, using suspension culture of an African Burkitt's lymphoma derived cell line Namalva with induction by Newcastle disease virus, B-1 strain. Cell cultures were grown in impeller-driven 50-liter fermentors with dilution of the postinduction culture using serum-free medium. High levels of dissolved oxygen were necessary for optimum cell growth. A total of 4,207 liters of interferon culture was produced in a series of 116 fermentor runs. An average yield of 3.5 log(10) international units of interferon per ml was realized before processing. Trichloroacetic acid was used to precipitate the interferon. An average of 3.35 log(10) international units of interferon per ml was recovered in the final nonpurified product.

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Year:  1979        PMID： 464569      PMCID： PMC352676          DOI： 10.1128/AAC.15.3.420

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Interferon: purification and initial characterization from human diploid cells.

Authors:  E Knight
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205

2.  Production of human lymphoblastoid interferon.

Authors:  H Strander; K E Mogensen; K Cantell
Journal:  J Clin Microbiol       Date:  1975-01       Impact factor: 5.948

3.  A sensitive interferon assay for many species of cells: encephalomyocarditis virus hemagglutinin yield reduction.

Authors:  P Jameson; M A Dixon; S E Grossberg
Journal:  Proc Soc Exp Biol Med       Date:  1977-06

Review 4.  Antiviral activity of interferons.

Authors:  R M Friedman
Journal:  Bacteriol Rev       Date:  1977-09

5.  Production of human lymphoblastoid interferon by Namalva cells.

Authors:  K C Zoon; C E Buckler; P J Bridgen; D Gurari-Rotman
Journal:  J Clin Microbiol       Date:  1978-01       Impact factor: 5.948

6.  Human lymphoblastoid interferon. Large scale production and partial purification.

Authors:  P J Bridgen; C B Anfinsen; L Corley; S Bose; K C Zoon; U T Rüegg; C E Buckler
Journal:  J Biol Chem       Date:  1977-10-10       Impact factor: 5.157

7.  Human interferon: mass production in a newly established cell line, MG-63.

Authors:  A Billiau; V G Edy; H Heremans; J Van Damme; J Desmyter; J A Georgiades; P De Somer
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

8.  Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.

Authors:  G Klein; L Dombos; B Gothoskar
Journal:  Int J Cancer       Date:  1972-07-15       Impact factor: 7.396

9.  Human lymphoblastoid cells as a source of interferon.

Authors:  N B Finter; K H Fantes; M Johnston
Journal:  Dev Biol Stand       Date:  1977 Apr 13-15

10.  Administration of human fibroblast interferon in chronic hepatitis-B infection.

Authors:  J Desmyter; J De Groote; V J Desmet; A Billiau; M B Ray; A F Bradburne; V G Edy; P De Somer
Journal:  Lancet       Date:  1976-09-25       Impact factor: 79.321
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  10 in total

1.  Optimization of cell culture conditions for production of biologically active proteins.

Authors:  S Hosoi; H Miyaji; M Satoh; T Kurimoto; A Mihara; N Fujiyoshi; S Itoh; S Sato
Journal:  Cytotechnology       Date:  1991-01       Impact factor: 2.058

2.  Purification and partial characterization of human lymphoblast interferon.

Authors:  K C Zoon; M E Smith; P J Bridgen; D zur Nedden; C B Anfinsen
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

3.  Replacement of animal serum proteins by human albumin for growth and interferon production by Namalva cells.

Authors:  A K Field; E M Scattergood; C J Hopke; A A Tytell; M R Hilleman
Journal:  Antimicrob Agents Chemother       Date:  1980-12       Impact factor: 5.191

4.  Cell cultures producing human interferon.

Authors:  P C Familletti; S Pestka
Journal:  Antimicrob Agents Chemother       Date:  1981-07       Impact factor: 5.191

5.  Production of high levels of human leukocyte interferon from a continuous human myeloblast cell culture.

Authors:  P C Familletti; R McCandliss; S Pestka
Journal:  Antimicrob Agents Chemother       Date:  1981-07       Impact factor: 5.191

6.  Interferon production by a human lymphoblastoid cell line (DG-75) free of the Epstein-Barr genome.

Authors:  A Lazar; S Reuveny; M Minai; A Traub; A Mizrahi
Journal:  Antimicrob Agents Chemother       Date:  1981-08       Impact factor: 5.191

7.  Membrane ultrafiltration: concentration of interleukin-3.

Authors:  F Klein; R T Ricketts; T R Rohrer; W I Jones; P M Clark; M C Flickinger
Journal:  Appl Environ Microbiol       Date:  1984-05       Impact factor: 4.792

8.  Stable production of recombinant pro-urokinase by human lymphoblastoid Namalwa KJM-1 cells: host-cell dependency of the expressed-protein stability.

Authors:  M Satoh; S Hosoi; H Miyaji; S Itoh; S Sato
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

9.  Combined protective effects on interferon and interferon induction on herpes simplex and ectromelia virus infections in mice.

Authors:  J Imanishi; M Matsubara; C J Won; H Nomura; T Kishida
Journal:  Antimicrob Agents Chemother       Date:  1981-05       Impact factor: 5.191

10.  Oncolytic rat parvovirus H-1PV, a candidate for the treatment of human lymphoma: In vitro and in vivo studies.

Authors:  Assia L Angelova; Marc Aprahamian; Ginette Balboni; Henri-Jacques Delecluse; Regina Feederle; Irina Kiprianova; Svitlana P Grekova; Angel S Galabov; Mathias Witzens-Harig; Anthony D Ho; Jean Rommelaere; Zahari Raykov
Journal:  Mol Ther       Date:  2009-04-14       Impact factor: 11.454
  10 in total

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