Literature DB >> 6169305

Interferon production by a human lymphoblastoid cell line (DG-75) free of the Epstein-Barr genome.

A Lazar, S Reuveny, M Minai, A Traub, A Mizrahi.   

Abstract

A new lymphoblastoid cell line, DG-75, was investigated for its ability to produce interferon. DG-75 cells, previously shown to be free of Epstein-Barr virus genome and receptors, could be grown in submerged culture and could produce interferon in titers comparable to interferon produced by Namalva cells. The interferon produced was similar in size to the Namalva interferon as determined by gel filtration in Ultrogel AcA54. The DG-75 cells present a new source of large quantities of interferon which may be safer for human use than the Namalva interferon.

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Year:  1981        PMID: 6169305      PMCID: PMC181655          DOI: 10.1128/AAC.20.2.151

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  17 in total

1.  Production of human lymphoblastoid interferon.

Authors:  H Strander; K E Mogensen; K Cantell
Journal:  J Clin Microbiol       Date:  1975-01       Impact factor: 5.948

Review 2.  Classification and biological nature of established human hematopoietic cell lines.

Authors:  K Nilsson; J Pontén
Journal:  Int J Cancer       Date:  1975-02-15       Impact factor: 7.396

Review 3.  Interferons: anti-neoplastic drugs?

Authors:  H Strander
Journal:  Blut       Date:  1977-09-18

4.  Pronounced antiviral activity of human interferon on bovine and porcine cells.

Authors:  I Gresser; M T Bandu; D Brouty-boye; M Tovey
Journal:  Nature       Date:  1974-10-11       Impact factor: 49.962

5.  Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.

Authors:  G Klein; L Dombos; B Gothoskar
Journal:  Int J Cancer       Date:  1972-07-15       Impact factor: 7.396

6.  Fluorometric assay of proteins in the nanogram range.

Authors:  P Böhlen; S Stein; W Dairman; S Udenfriend
Journal:  Arch Biochem Biophys       Date:  1973-03       Impact factor: 4.013

7.  Production of high-titered interferon in cultures of human diploid cells.

Authors:  E A Havell; J Vilcek
Journal:  Antimicrob Agents Chemother       Date:  1972-12       Impact factor: 5.191

8.  Microassay for human and chick cell interferons.

Authors:  J G Tilles; M Finland
Journal:  Appl Microbiol       Date:  1968-11

Review 9.  Human leukocyte interferon: production, purification, stability, and animal experiments.

Authors:  K Cantell; S Hirvonen; K E Mogensen; L Pyhälä
Journal:  In Vitro Monogr       Date:  1974

10.  Establishment in continuous culture of a new type of lymphocyte from a "Burkitt like" malignant lymphoma (line D.G.-75).

Authors:  H Ben-Bassat; N Goldblum; S Mitrani; T Goldblum; J M Yoffey; M M Cohen; Z Bentwich; B Ramot; E Klein; G Klein
Journal:  Int J Cancer       Date:  1977-01       Impact factor: 7.396

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  3 in total

1.  Critical role for endocytosis in the regulation of signaling by the Kaposi's sarcoma-associated herpesvirus K1 protein.

Authors:  Christine C Tomlinson; Blossom Damania
Journal:  J Virol       Date:  2008-04-23       Impact factor: 5.103

2.  The production of interferon-alpha and -beta by cloned human lymphoblastoid cells. Brief report.

Authors:  S Hoshino; J Imanishi; H Matsuoka; T Kishida
Journal:  Arch Virol       Date:  1983       Impact factor: 2.574

3.  Hemophagocytic macrophages harbor Salmonella enterica during persistent infection.

Authors:  Rebecca N Nix; Sarah E Altschuler; Peter M Henson; Corrella S Detweiler
Journal:  PLoS Pathog       Date:  2007-12       Impact factor: 6.823

  3 in total

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