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Literature DB >> 3883346

Involvement of ribosomal protein L7/L12 in control of translational accuracy.

Abstract

The effects of two mutations, which map at the rplL locus and both give a changed 50S ribosomal protein L7/L12, were studied. Both mutations are associated with an increased misreading of all three nonsense codons in vivo and ribosomes from the mutants give an increased misreading of the phenylalanine codon UUU by tRNALeu in vitro. The rplL-associated misreading in vitro is not limited to a particular type of mRNA or tRNA. Results from a translational proofreading assay, using mutant ribosomes, suggest that protein L7/L12 is involved in the control of translational accuracy by contributing to the efficiency of a translational proofreading step(s).

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Year: 1985 PMID： 3883346 PMCID： PMC397117 DOI： 10.1073/pnas.82.3.717

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

37 in total

1. Effect of different mutations in ribosomal protein S5 of Escherichia coli on translational fidelity.

Authors: W Piepersberg; A Böck; H G Wittmann
Journal: Mol Gen Genet Date: 1975-09-29

2. Kinetic amplification of enzyme discrimination.

Authors: J Ninio
Journal: Biochimie Date: 1975 Impact factor: 4.079

3. Cooperative control of translational fidelity by ribosomal proteins in Escherichia coli. III. A ram mutation in the structural gene for protein S5 (rpx E).

Authors: T Cabezón; A Herzog; M De Wilde; R Villarroel; A Bollen
Journal: Mol Gen Genet Date: 1976-02-27

4. Role of ribosomal protein S12 in discrimination of aminoacyl-tRNA.

Authors: J L Yates
Journal: J Biol Chem Date: 1979-11-25 Impact factor: 5.157

5. Culture medium for enterobacteria.

Authors: F C Neidhardt; P L Bloch; D F Smith
Journal: J Bacteriol Date: 1974-09 Impact factor: 3.490

6. Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity.

Authors: J J Hopfield
Journal: Proc Natl Acad Sci U S A Date: 1974-10 Impact factor: 11.205

7. Instability of a missense suppressor resulting from a duplication of genetic material.

Authors: C W Hill; J Foulds; L Soll; P Berg
Journal: J Mol Biol Date: 1969-02-14 Impact factor: 5.469

8. New chromosomal location for structural genes of ribosomal proteins.

Authors: R J Watson; J Parker; N P Fiil; J G Flaks; J D Friesen
Journal: Proc Natl Acad Sci U S A Date: 1975-07 Impact factor: 11.205

9. Alteration of ribosomal protein S17 by mutation linked to neamine resistance in Escherichia coli. I. General properties of neaA mutants.

Authors: A Bollen; T Cabezón; M de Wilde; R Villarroel; A Herzog
Journal: J Mol Biol Date: 1975-12-25 Impact factor: 5.469

10. Induction kinetics of the L-arabinose operon of Escherichia coli.

Authors: R Schleif; W Hess; S Finkelstein; D Ellis
Journal: J Bacteriol Date: 1973-07 Impact factor: 3.490

33 in total

1. Single-base mutations at position 2661 of Escherichia coli 23S rRNA increase efficiency of translational proofreading.

Authors: P Melançon; W E Tapprich; L Brakier-Gingras
Journal: J Bacteriol Date: 1992-12 Impact factor: 3.490

9. Nuclear-encoded chloroplast ribosomal protein L12 of Nicotiana tabacum: characterization of mature protein and isolation and sequence analysis of cDNA clones encoding its cytoplasmic precursor.

Authors: G A Elhag; F J Thomas; T P McCreery; D P Bourque
Journal: Nucleic Acids Res Date: 1992-02-25 Impact factor: 16.971

10. Ribosomal protein L7/L12 has a helix-turn-helix motif similar to that found in DNA-binding regulatory proteins.

Authors: P A Rice; T A Steitz
Journal: Nucleic Acids Res Date: 1989-05-25 Impact factor: 16.971

Involvement of ribosomal protein L7/L12 in control of translational accuracy.

1. Effect of different mutations in ribosomal protein S5 of Escherichia coli on translational fidelity.

2. Kinetic amplification of enzyme discrimination.

3. Cooperative control of translational fidelity by ribosomal proteins in Escherichia coli. III. A ram mutation in the structural gene for protein S5 (rpx E).

4. Role of ribosomal protein S12 in discrimination of aminoacyl-tRNA.

5. Culture medium for enterobacteria.

6. Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity.

7. Instability of a missense suppressor resulting from a duplication of genetic material.

8. New chromosomal location for structural genes of ribosomal proteins.

9. Alteration of ribosomal protein S17 by mutation linked to neamine resistance in Escherichia coli. I. General properties of neaA mutants.

10. Induction kinetics of the L-arabinose operon of Escherichia coli.

1. Single-base mutations at position 2661 of Escherichia coli 23S rRNA increase efficiency of translational proofreading.

2. Novel mutants of 23S RNA: characterization of functional properties.

3. A ribosomal ambiguity mutation in the 530 loop of E. coli 16S rRNA.

4. Suppression of the Escherichia coli rpoH opal mutation by ribosomes lacking S15 protein.

5. Accumulation of a mRNA decay intermediate by ribosomal pausing at a stop codon.

6. Control of phosphate release from elongation factor G by ribosomal protein L7/12.

Review 7. Transfer ribonucleic acid-mediated suppression of termination codons in Escherichia coli.

Review 8. Errors and alternatives in reading the universal genetic code.

9. Nuclear-encoded chloroplast ribosomal protein L12 of Nicotiana tabacum: characterization of mature protein and isolation and sequence analysis of cDNA clones encoding its cytoplasmic precursor.

10. Ribosomal protein L7/L12 has a helix-turn-helix motif similar to that found in DNA-binding regulatory proteins.