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Literature DB >> 1182215

Kinetic amplification of enzyme discrimination.

Abstract

The dependence of the accuracy of enzymatic systems on the mechanism of the catalyzed reaction is investigated, using a probabilistic approach. Certain mechanisms of reaction, involving a delay in one of the steps act as kinetic amplifiers of molecular discriminations. The relationship between our scheme for a delayed reaction [1] and Hopfield's scheme [i] is discussed.

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Year: 1975 PMID： 1182215 DOI： 10.1016/s0300-9084(75)80139-8

Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079

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Cited

189 in total

1. Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation.

Authors: J Paulsson; O G Berg; M Ehrenberg
Journal: Proc Natl Acad Sci U S A Date: 2000-06-20 Impact factor: 11.205

2. The accuracy of codon recognition by polypeptide release factors.

Authors: D V Freistroffer; M Kwiatkowski; R H Buckingham; M Ehrenberg
Journal: Proc Natl Acad Sci U S A Date: 2000-02-29 Impact factor: 11.205

3. Fluctuations in repressor control: thermodynamic constraints on stochastic focusing.

Authors: O G Berg; J Paulsson; M Ehrenberg
Journal: Biophys J Date: 2000-12 Impact factor: 4.033

4. Analysis of codon:anticodon interactions within the ribosome provides new insights into codon reading and the genetic code structure.

Authors: V I Lim; J F Curran
Journal: RNA Date: 2001-07 Impact factor: 4.942

Kinetic amplification of enzyme discrimination.

1. Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation.

2. The accuracy of codon recognition by polypeptide release factors.

3. Fluctuations in repressor control: thermodynamic constraints on stochastic focusing.

4. Analysis of codon:anticodon interactions within the ribosome provides new insights into codon reading and the genetic code structure.

Review 5. Signaling cascades: escape from kinetic proofreading.

6. The role of proofreading in signal transduction specificity.

7. The Influence of Look-Ahead on the Error Rate of Transcription.

8. Amplifying signal transduction specificity without multiple phosphorylation.

Review 9. Fidelity at the molecular level: lessons from protein synthesis.

10. Causes of aging are likely to be many: robin holliday and changing molecular approaches to cell aging, 1963-1988.