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Literature DB >> 3458666

A multipoint linkage analysis program for X-linked disorders, with the example of Duchenne muscular dystrophy and seven DNA probes.

Abstract

The analysis of linkage data with multiple markers is a complex problem, only soluble with the help of computer programs. A package of programs is presented which allows the analysis of X-linked data with reasonable speed. Published data relating Duchenne muscular dystrophy and seven X-specific DNA probes are analysed. The results presented are the maximum likelihoods of the eight possible orders and the interlocus distances of the most likely order. Also calculated are the mean and standard deviation of risk for selected cases with information derived from both single probes and pair of probes bridging the disease locus.

Entities: Disease

Mesh：

Substances：
Genetic Markers
DNA

Year: 1986 PMID： 3458666 DOI： 10.1007/BF00292667

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

10 in total

Review 1. Molecular genetics of the human X chromosome.

Authors: K E Davies
Journal: J Med Genet Date: 1985-08 Impact factor: 6.318

2. A computer programme to calculate risk in X linked disorders using multiple marker loci.

Authors: J F Clayton
Journal: J Med Genet Date: 1986-02 Impact factor: 6.318

3. Report of the Committee on Methods of Linkage Analysis and Reporting.

Authors: P M Conneally; J H Edwards; K K Kidd; J M Lalouel; N E Morton; J Ott; R White
Journal: Cytogenet Cell Genet Date: 1985

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Authors: R C Elston; J Stewart
Journal: Hum Hered Date: 1971 Impact factor: 0.444

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Authors: J H Renwick; D R Bolling
Journal: J Med Genet Date: 1971-12 Impact factor: 6.318

6. DNA in medicine. Human genetics.

Authors: R L White
Journal: Lancet Date: 1984-12-01 Impact factor: 79.321

7. A mapping function for man.

Authors: D C Rao; N E Morton; J Lindsten; M Hultén; S Yee
Journal: Hum Hered Date: 1977 Impact factor: 0.444

8. Strategies for multilocus linkage analysis in humans.

Authors: G M Lathrop; J M Lalouel; C Julier; J Ott
Journal: Proc Natl Acad Sci U S A Date: 1984-06 Impact factor: 11.205

9. Multipoint linkage analysis of the short arm of the human X chromosome in families with X-linked muscular dystrophy.

Authors: D E Wilcox; N A Affara; J R Yates; M A Ferguson-Smith; P L Pearson
Journal: Hum Genet Date: 1985 Impact factor: 4.132

10. Genetic linkage relationships of seven DNA probes with Duchenne and Becker muscular dystrophy.

Authors: C S Brown; N S Thomas; M Sarfarazi; K E Davies; L Kunkel; P L Pearson; H M Kingston; D J Shaw; P S Harper
Journal: Hum Genet Date: 1985 Impact factor: 4.132

10 in total

7 in total

1. Linkage studies and deletion screening in choroideremia.

Authors: A F Wright; R L Nussbaum; S S Bhattacharya; M Jay; J G Lesko; H J Evans; B Jay
Journal: J Med Genet Date: 1990-08 Impact factor: 6.318

2. Efficient computations in multilocus linkage analysis.

Authors: G M Lathrop; J M Lalouel
Journal: Am J Hum Genet Date: 1988-03 Impact factor: 11.025

3. Linkage relationships between X-linked retinitis pigmentosa and nine short-arm markers: exclusion of the disease locus from Xp21 and localization to between DXS7 and DXS14.

Authors: A F Wright; S S Bhattacharya; J F Clayton; M Dempster; P Tippett; C M McKeown; M Jay; B Jay; A C Bird
Journal: Am J Hum Genet Date: 1987-10 Impact factor: 11.025

Review 4. DNA analysis in human disease.

Authors: A F Wright
Journal: J Clin Pathol Date: 1986-12 Impact factor: 3.411